Article
Cell Biology
Li-Na Wang, Xue-Zhi Wang, Yu-Jia Li, Bing-Rong Li, Meng Huang, Xiao-Yu Wang, Ryszard Grygorczyk, Guang-Hong Ding, Wolfgang Schwarz
Summary: This review provides experimental evidence that subcutaneous mast cells play a role in the analgesic effects of acupuncture. The manipulation of acupuncture needles activates mast cells, leading to the release of various mediators that reduce the electrical activities of sensory neurons, resulting in analgesia. This finding is of great significance in further understanding the mechanisms of acupuncture.
Article
Orthopedics
Soo-Hong Han, Hyung Kyung Kim, Yoon Jang, Hyeon Hae Lee, Jeongbae Rhie, Donghun Han, Jongbeom Oh, Soonchul Lee
Summary: In this study, it was found that increased expression of SP and CGRP in biopsy samples of lateral epicondylitis patients was associated with tendon degeneration severity. The levels of SP and CGRP expression were significantly correlated with Movin score, with higher levels associated with more severe degeneration. Additionally, elevated SP or CGRP expression levels were also linked with higher preoperative VAS scores.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, Legal
Antonio Guzam, Araceli Tortajada, Ana-Paz Marin, Cristina Vila, Gregorio Encina
Summary: Cizolirtine, a substance used for pain and urinary incontinence, showed an increased incidence of tumors in mice and rats. In mice, it was associated with an increase in skin fibrosarcomas and sarcomas, while in rats, it was associated with liver adenomas and carcinomas, possibly due to increased liver metabolism and related changes. However, the relevance of these findings to humans remains uncertain.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Legal
Antonio Guzman, Gregorio Encina, Antonio R. Fernandez de Henestrosa, Cristina Vila, Araceli Tortajada, Ana-Paz Marin
Summary: Cizolirtine treatment in rats showed adverse effects such as decreased bodyweight gain and increased plasma concentrations. High doses led to liver and ovarian issues in some animals. The dosages of 20 and 60 mg/kg/day were considered as the No-Observed-Adverse-Effect Levels for males and females respectively.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Neurosciences
Rui-hao Zhang, Xiao-bo Zhang, Yu-bao Lu, Yi-cun Hu, Xiang-yi Chen, De-chen Yu, Jin-tao Shi, Wen-huan Yuan, Jing Wang, Hai-yu Zhou
Summary: This study found that the expression of CGRP in the femur of osteoporotic patients was downregulated, while the expression of CGRP and serotonin in the spinal cord and brainstem was increased. These results suggest that the activation of osteoclasts may trigger the release of CGRP from sensory nerve fibers and promote serotonin release in the spinal cord and brainstem, contributing to bone loss in postmenopausal osteoporosis.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Dongni Xie, Yamei Xu, Yao Yang, Ziyi Hua, Jiao Li, Gang Fu, Qingqing Wu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of systematic administration of bisphosphonates (BPs). Sensory denervation facilitates the occurrence of BRONJ, but therapeutic use of CGRP can effectively prevent the progression of BRONJ.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Immunology
Yu Fan, Do-Hee Kim, Young Seob Gwak, Danbi Ahn, Yeonhee Ryu, Suchan Chang, Bong Hyo Lee, Kyle B. Bills, Scott C. Steffensen, Chae Ha Yang, Hee Young Kim
Summary: Acupuncture, used for over 2500 years, triggers acupuncture signaling and effects through the release of neuropeptides during neurogenic inflammation, enhancing sensory afferents' responses to needling at acupoints.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Immunology
Jingya Zhang, Siqi Zhao, Xinzhu Xing, Lin Shang, Jiali Cao, Yanling He
Summary: Psoriasis is an autoimmune disease characterized by discolored, scaled patches of skin. Psychological factors have been found to often trigger or worsen the disease. Current research indicates that the nervous and immune systems play a role in the pathogenesis of psoriasis. This article explores the impact of neuropeptides on dendritic cells in psoriasis and suggests that inhibiting these neuropeptides can improve skin lesions, making neuroimmune response a potential direction for new drug treatments and perspectives in psoriasis development.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dubravka Vukovic, Marin Ogorevc, Ivo Tripkovic, Neira Puizina-Ivic, Mirna Saraga-Babic, Snjezana Mardesic
Summary: LS patients show abnormal distribution and density of nerve fibers, increased density of macrophages and mast cells in the skin. Genital and extragenital LS have different pathological characteristics. These findings provide insights into the pathogenesis of LS and suggest potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Yoo Jung Yi, Do Hee Kim, Suchan Chang, Yeonhee Ryu, Sang Chan Kim, Hee Young Kim
Summary: Neurogenic spots in the rat model of liver injury induced by bile duct ligation function as acupoints and have therapeutic effects on hepatic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Wei Liu, Chang Rao, Qi Zhao, Yuzheng Du, Xi Nan, Zefang Li, Chunsheng Yin
Summary: A meta-analysis will be conducted to evaluate the effectiveness of manual acupuncture therapy on post-stroke depression, with a systematic search on English, Chinese, and Japanese databases. The results will be disseminated through publication in peer-reviewed journals or conference presentations.
Article
Immunology
Yuanyuan Ding, Baowen Dang, Yuejin Wang, Chenrui Zhao, Hongli An
Summary: Artemisinic acid was found to inhibit mast cell degranulation, alleviate symptoms of chronic urticaria, and mitigate allergic reactions through specific signaling pathways. Artemisinic acid has the potential as a treatment for allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Aiko Oyamaguchi, Hiroshi Hanamoto, Yoshiki Tanaka, Sayo Takahashi, Hitoshi Niwa
Summary: The study aimed to investigate the effects of manual acupuncture (MA) and electroacupuncture (EA) on current perception thresholds (CPTs) using quantitative methods. Twenty-nine healthy volunteers participated in the study. Both MA and EA increased the sensory thresholds of A beta, A delta, and C-fibers in the mental region for > 30 min after needle removal. The additional electrical stimulation did not provide additional benefits compared to needling alone.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Immunology
Shammy Raj, Stepan Hlushak, Narcy Arizmendi, Andriy Kovalenko, Marianna Kulka
Summary: Mast cells are activated by IgE receptors and MRGPRX2, and the activation by MRGPRX2 causes the internalization of MRGPRX2 within a short time. The interaction between MRGPRX2 and substance P is facilitated by hydrogen bonds and salt bridges.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Ying Wang, Mang Yu, Kazufumi Matsushita, Chen Liu, Naotada Ishihara, Masatoshi Nomura, Mindy Tsai, Stephen J. Galli
Summary: This study reveals that the protein Drp1 can differentially regulate the activation of mast cells by different stimuli. Promoting or inhibiting Drp1 activation might represent novel approaches for treating IgE-dependent mast cell activation or mitigating other substance P-induced mast cell-dependent responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)