Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Ryuichi Hirota, Zen-ichiro Katsuura, Naoki Momokawa, Hiroki Murakami, Satoru Watanabe, Takenori Ishida, Takeshi Ikeda, Hisakage Funabashi, Akio Kuroda
Summary: In this study, it was found that under specific conditions, a phosphite-dependent strain of Escherichia coli can generate escape mutants. The mutation occurs at position 210 of the transmembrane domain protein HtxC of the phosphorus compound transporter HtxBCDE. The replacement of a specific amino acid residue at this position can reduce the rate of escape mutant generation.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jun Gyou Park, Songwon Kim, Eunhong Jang, Seung Hun Choi, Hyunsu Han, Seulgi Ju, Ji Won Kim, Da Sol Min, Mi Sun Jin
Summary: This study reveals that TAPL functions as a peptide translocator and a phosphatidylserine floppase. The cryo-EM structures of TAPL complexed with phospholipids, cholesteryl hemisuccinate, and peptide provide insights into its mechanism of action.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Fiza Liaquat, Muhammad Farooq Hussain Munis, Samiah Arif, Muhammad Aamir Manzoor, Urooj Haroon, Iftikhar Hussain Shah, Muhammad Ashraf, Hyun Seok Kim, Shengquan Che, Liu Qunlu
Summary: This study investigated the differential gene expression of Schima superba under Mn metal stress through transcriptomic analysis. The differentially expressed genes were found to be involved in defense, signaling pathways, oxidative burst, transcription factors, and stress responses. The results provide insights into the metal resistance mechanisms and contribute to the understanding of heavy metal tolerance and detoxification.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yaolei Mi, Xue Cao, Xuewen Zhu, Weiqiang Chen, Xiangxiao Meng, Huihua Wan, Wei Sun, Sifan Wang, Shilin Chen
Summary: This study identified and characterized 113 ABC transporters in C. sativa, and proposed seven core transporters that may participate in cannabinoid transport. These candidate genes showed high correlation with cannabinoid biosynthetic pathway genes and content, and were highly expressed in cannabinoid biosynthesis and accumulation sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Marie, Irene Hernandez-Lozano, Oliver Langer, Nicolas Tournier
Summary: Hepatocyte transporters play a crucial role in the hepatobiliary elimination of various substances, influenced by different pathophysiological conditions and specific drugs; Tc-99m-mebrofenin has been used for hepatobiliary scintigraphy for years, but the specific transporters controlling its liver kinetics have only recently been characterized; Pharmacokinetic modeling offers a translational method to study transporter-mediated drug interactions, providing insights into liver function as a biomarker.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Silpa Narayanan, Zhuo-Xun Wu, Jing-Quan Wang, Hansu Ma, Nikita Acharekar, Jagadish Koya, Sabesan Yoganathan, Shuo Fang, Zhe-Sheng Chen, Yihang Pan
Summary: In this study, GS-9973 showed efficacy in overcoming ABCG2-mediated multidrug resistance in non-small cell lung cancer cells. The drug reversed drug resistance by blocking ABCG2 efflux activity and downregulating ABCG2 expression at the protein level, suggesting it as a potential strategy to overcome MDR in cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Applied
Alba M. Garcia-Lino, Alex Gomez-Gomez, Dafne Garcia-Mateos, Alvaro de la Fuente, Ana I. Alvarez, Oscar J. Pozo, Gracia Merino
Summary: ABCG2 is involved in the secretion of several compounds in milk, with higher levels of tryptophan-related compounds in wild-type mice compared to Abcg2(-/-) mice. The milk-to-plasma ratio of these compounds was also higher in dairy cows carrying the ABCG2 Y581S polymorphism compared to noncarrier animals. In vitro transport assays confirmed these findings and validated differences in the bovine protein variants.
Article
Nutrition & Dietetics
Yoon-Young Sung, Dong-Seon Kim
Summary: The study found that eggshell membrane (EM) exhibits antihyperuricemic effects by promoting renal urate excretion and regulating renal urate transporters, resulting in reduced serum uric acid levels in hyperuricemic rats.
Article
Pharmacology & Pharmacy
Louise Breuil, Nora Ziani, Sarah Leterrier, Gaelle Hugon, Fabien Caille, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sebastien Goutal, Nicolas Tournier
Summary: This study investigated the impact of CYP inducers and inhibitors on the brain and plasma kinetics of [C-11]metoclopramide using PET imaging. The results showed that CYP induction or inhibition had negligible effects on the plasma kinetics and metabolism of [C-11]metoclopramide, but ritonavir significantly increased brain penetration.
Article
Biochemistry & Molecular Biology
Methinee Pipatthana, Phurt Harnvoravongchai, Pisut Pongchaikul, Somsak Likhitrattanapisal, Matthew Phanchana, Surang Chankhamhaengdecha, Tavan Janvilisri
Summary: This study analyzed the sequence-function relationship of ABC proteins in Clostridioides difficile, revealing different protein domains associated with the ABC system and the gene organization within the genome. The classification and genetic structure of ABC transporters were identified, with a focus on the significant role of these proteins in antibiotic resistance, providing insights into the function and evolutionary relationships of ABC proteins in this pathogen.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Marine & Freshwater Biology
Hye-Min Kang, Eunjin Byeon, Haksoo Jeong, Yoseop Lee, Un-Ki Hwang, Chang-Bum Jeong, Cheolho Yoon, Jae-Seong Lee
Summary: This study examined the combined effects of nano(micro)plastics (NMPs) and arsenic (As) on the marine rotifer Brachionus plicatilis. The results showed that NPs increased As toxicity while MPs alleviated it, and NPs inhibited the efflux of As. These findings provide a deeper understanding of the environmental pollutants and their interactions.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qingshan Luo, Huigang Shi, Xueqing Xu
Summary: Lipopolysaccharide (LPS) is a crucial component of the outer membrane in most Gram-negative bacteria, and its transport from the inner membrane to the outer membrane is facilitated by seven lipopolysaccharide transport proteins. This study presents the cryo-EM structures of LptB(2)FG and LptB(2)FGC from Klebsiella pneumoniae, highlighting the detailed interactions between LPS and the transporter.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Gangyang Wang, Lingling Cao, Yafei Jiang, Tao Zhang, Hongsheng Wang, Zhuoying Wang, Jing Xu, Min Mao, Yingqi Hua, Zhengdong Cai, Xiaojun Ma, Shuo Hu, Chenghao Zhou
Summary: This study demonstrates that anlotinib can reverse multidrug resistance in osteosarcoma cells by inhibiting the efflux function of P-glycoprotein 1 (PGP1) and increasing the intracellular accumulation of chemotherapeutic agents. Anlotinib also stimulates the ATPase activity of PGP1. In animal studies, anlotinib combined with doxorubicin shows a significant decrease in tumor growth rate and tumor size.
FRONTIERS IN PHARMACOLOGY
(2022)