Article
Agriculture, Multidisciplinary
Yue Li, Teng Wang, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Qing-Rong Huang, Tian-Tian Zhang
Summary: Sea cucumber-derived sulfated sterols showed more significant bioactivities due to the unique structure of the sulfate group, but their absorption, pharmacokinetics, and tissue distribution remain unknown. This study investigated the absorption characteristics, pharmacokinetics, and tissue distribution of sea cucumber sterols, finding that they are absorbed quickly and mainly accumulate in the liver. These results provide insights for the development of functional foods and nutraceuticals containing sea cucumber sterols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Ying Li, Hang Su, Zhong-Ping Yin, Jing-En Li, En Yuan, Qing-Feng Zhang
Summary: This study investigated the metabolism, tissue distribution, and excretion of taxifolin in rats after oral administration of taxifolin encapsulated zein-caseinate nanoparticles (TZP). Isomerization of taxifolin was found in the rat's small intestine and colon. UPLC-QTOF-MS analysis identified 16 metabolites of taxifolin in rat feces, plasma, and urine. Taxifolin underwent hydration, dehydration, and ring fission metabolism in the colon through gut microflora. The main metabolites detected in plasma and urine were sulfated, glucuronidated, and/or methylated products of taxifolin. The dynamic variation of taxifolin and its metabolites in tissues and urine were quantified using UPLC-QqQ-MS/MS. Taxifolin and its metabolites were rapidly absorbed and distributed in tissues, with lower concentrations found in the heart and brain. Feces excretion of taxifolin was determined by HPLC, and the total excretion within 24 hours was 2.83 +/- 0.80% of the given dose, with the highest excretion occurring during 8-10 hours post administration. Compared to feces, the excretion of taxifolin and its metabolites in urine was much faster, with a total excretion of 1.96 +/- 0.23% within 12 hours.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Lei He, Donglin Feng, Hui Guo, Yueyuan Zhou, Zhaozhao Li, Kuo Zhang, Wangqian Zhang, Shuning Wang, Zhaowei Wang, Qiang Hao, Cun Zhang, Yuan Gao, Jintao Gu, Yingqi Zhang, Weina Li, Meng Li
Summary: This study provides the first analysis of the pharmacokinetics of BPC157, showing linear pharmacokinetic characteristics in rats and beagle dogs. The main excretory pathways of BPC157 were found to be urine and bile. These findings are important for the clinical translation of BPC157.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenhao Cheng, Siyang Wu, Zheng Yuan, Weiyu Hu, Xin Yu, Nianxin Kang, Qiutao Wang, Mingying Zhu, Kexin Xia, Wei Yang, Chen Kang, Shuofeng Zhang, Yingfei Li
Summary: Through a multicompound pharmacokinetic analysis, the tissue distribution and excretion characteristics of Radix Polygoni Multiflori (RPM) components were investigated. The findings showed that the active ingredients of RPM were quickly absorbed after oral administration and had high tissue distribution in the liver and kidney. These components were key contributors to the effectiveness and toxicity of RPM on the liver and kidney.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingqi Li, Qi Zhang, Yutong Chen, Chengyu Lu, Yongbin Tong
Summary: This study investigated the pharmacokinetic parameters of demethyleneberberine and compared its pharmacokinetics, tissue distribution, and excretion in rats and mice for the first time. The results showed that demethyleneberberine had high bioavailability in animals, which is of great significance for pharmacological and clinical research.
Article
Pharmacology & Pharmacy
Dong Wook Kang, Ju Hee Kim, Kyung Min Kim, Seok-jin Cho, Hee-Woon Jang, Ji Won Chang, Seung Myung Dong, Jee Woong Lim, Jae-Sun Kim, Hea-Young Cho
Summary: The study evaluated the pharmacokinetics and tissue distribution of the edaravone oral prodrug TEJ-1704 in rats and dogs. Results showed continuous metabolism of TEJ-1704 into edaravone, with distribution mainly in the heart, lung, and kidney, and equal excretion via urine and feces. Further studies are needed to fully understand the differences between TEJ-1704 and edaravone, as well as to determine the potency of TEJ-1704.
Review
Pharmacology & Pharmacy
Elka S. Waller, Ben J. Yardeny, Wan Yun Fong, Xue Yi Gan, Stephen V. Jimenez, Yijun Pan, Joshua H. Abasszade, Joseph A. Nicolazzo
Summary: Alzheimer's disease not only affects the neurological system but may also have an impact on other non-neurological systems, affecting the metabolism and excretion of drugs. Therefore, dosage adjustments may be necessary to ensure optimal pharmacotherapy for individuals with Alzheimer's disease.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Xinchi Feng, Kun Wang, Shijie Cao, Liqin Ding, Feng Qiu
Summary: This study systematically investigated the pharmacokinetic and excretion profiles of berberine and its nine metabolites in rats. The results showed that berberine was rapidly metabolized and all nine metabolites could be detected in vivo. The excretion study revealed that 18.6% of berberine was excreted in feces as berberrubine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei, Chun Wang
Summary: The study showed that combined oral administration of CP-25 with LEF can promote the excretion of TER in urine, feces, and bile, while reducing its content in most tissues and organs, especially in the liver, potentially reducing LEF-induced liver injury.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kunqian Mu, Kaiwen Jiang, Yue Wang, Zihan Zhao, Song Cang, Kaishun Bi, Qing Li, Ran Liu
Summary: A LC-MS/MS method was developed to study the in vivo fate of beta-cyclodextrin. The results showed that beta-cyclodextrin has a wide distribution in rats' bodies and is rapidly excreted, indicating low accumulation and good safety.
Article
Chemistry, Medicinal
Liping Dong, Wenjuan Liu, Xiaoyuan Zhao, Feng Yu, Yungen Xu, Mengxiang Su
Summary: This study synthesized a novel limonin derivative, HY-071085, with strong anti-inflammatory and analgesic activity. The pharmacokinetics, bioavailability, distribution, and excretion of HY-071085 were evaluated in rats and beagle dogs. The results showed nonlinear dynamic characteristics and gender differences in the pharmacokinetics of HY-071085, as well as tissue distribution and excretion patterns.
Article
Pharmacology & Pharmacy
Xuguang Zhang, Zhenrui Xie, Xun Chen, Junqiang Qiu, Yinfeng Tan, Xiaoliang Li, Hailong Li, Junqing Zhang
Summary: Alpinia officinarum alters the pharmacokinetic parameters of indomethacin, reducing its systemic exposure and increasing elimination. Co-administration of A. officinarum does not reduce indomethacin accumulation in target tissues, but accelerates excretion of indomethacin and its metabolites. This suggests that A. officinarum may have a gastrointestinal protective effect through interactions with indomethacin in rats.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Lin Wang, Xiangping Li, Ying Kong, Furong Wang, Qiuyan Zhang, Chao Lin, Rong Rong
Summary: Compound 6c, a potent DPP-4 inhibitor, showed good antidiabetic activity and a long terminal half-life. A validated UPLC-MS/MS method was established for its quantification, revealing its pharmacokinetic behavior, distribution, and excretion in rats. Compound 6c exhibited linear pharmacokinetics and was detected in various tissues, suggesting potential effects on lung cancer or other respiratory diseases.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemical Research Methods
Jingwen Qiu, Mingjuan Zhu, Ying Wang, Bingying Chen, Rongyu Bai, Fenglian Chen, Yu Li, Yuan Zhou, Lei Zhang
Summary: This study is the first to investigate the pharmacokinetics and excretion of Toddalia asiatica extract after oral administration, which may offer a scientific foundation for its clinical applications. The established HPLC-MS/MS method was effective in simultaneously determining coumarins, alkaloids, and a flavonoid in rat feces, plasma, and urine.
ANALYTICAL BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov, Elena A. Baybulatova
Summary: Infections pose significant risks for elderly patients, with high consumption of antimicrobial agents leading to increased toxicity, organ deterioration, longer hospital stays, ICU admissions, disability, and even death. The efficacy and safety of antibiotics in the elderly are influenced by age-related changes in physiological and pathological factors, affecting drug absorption, distribution, metabolism, and excretion. Pharmacokinetic changes in elderly patients are also influenced by factors like body composition, nutritional status, and concomitant drug use. Understanding these age-related pharmacokinetic alterations is crucial for optimizing antibiotic therapy in the elderly.
Article
Biochemical Research Methods
Tsuyoshi Minematsu, Laurie Felder, Todd Oppeneer, Masashi Sakazume, Keishi Oikawa, Tadashi Hashimoto, Takashi Usui, Hidetaka Kamimura
BIOMEDICAL CHROMATOGRAPHY
(2008)
Article
Pharmacology & Pharmacy
Hisakazu Ohtani, Zoe Barter, Tsuyoshi Minematsu, Masatoshi Makuuchi, Yasufumi Sawada, Amin Rostami-Hodjegan
BIOPHARMACEUTICS & DRUG DISPOSITION
(2011)
Article
Pharmacology & Pharmacy
Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui, Hidetaka Kamimura
DRUG METABOLISM AND DISPOSITION
(2008)
Article
Pharmacology & Pharmacy
Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui, Hidetaka Kamimura
DRUG METABOLISM AND DISPOSITION
(2009)
Article
Pharmacology & Pharmacy
Megumi Iwai, Tsuyoshi Minematsu, Shinichi Narikawa, Takashi Usui, Hidetaka Kamimura
DRUG METABOLISM AND DISPOSITION
(2009)
Article
Pharmacology & Pharmacy
Tsuyoshi Minematsu, Megumi Iwai, Ken-Ichi Umehara, Takashi Usui, Hidetaka Kamimura
DRUG METABOLISM AND DISPOSITION
(2010)
Article
Pharmacology & Pharmacy
Megumi Iwai, Tsuyoshi Minematsu, Qun Li, Takafumi Iwatsubo, Takashi Usui
DRUG METABOLISM AND DISPOSITION
(2011)
Article
Oncology
Tsuyoshi Minematsu, Kathleen M. Giacomini
MOLECULAR CANCER THERAPEUTICS
(2011)
Article
Pharmacology & Pharmacy
T. Minematsu, T. Hashimoto, T. Usui, H. Kamimura
Article
Pharmacology & Pharmacy
Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka, Kenji Tabata
Article
Pharmacology & Pharmacy
Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka, Kenji Tabata
BIOPHARMACEUTICS & DRUG DISPOSITION
(2019)
Article
Pharmacology & Pharmacy
Hiroyuki Sayama, Diana Marcantonio, Takeyuki Nagashima, Masashi Shimazaki, Tsuyoshi Minematsu, Joshua F. Apgar, John M. Burke, Lucia Wille, Yasuhisa Nagasaka, Daniel C. Kirouac
Summary: A novel drug, ASP2453, has shown potential for greater clinical response compared to the more advanced competitor, AMG 510, in inhibiting KRAS(G12C) mutations. A quantitative systems pharmacology model linking KRAS signaling to tumor growth in non-small cell lung cancer patients was developed, with ASP2453 exhibiting impressive efficacy in preclinical data. The model predicted that ASP2453 has a more favorable clinical response, providing insight for potential differentiation and strategic planning in clinical trials.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yukio Otsuka, Srinivasu Poondru, Peter L. Bonate, Rachel H. Rose, Masoud Jamei, Fumihiko Ushigome, Tsuyoshi Minematsu
Summary: Enzalutamide strongly induces CYP3A4 and has both induction and inhibition effects on P-gp. A DDI study with digoxin suggested weak inhibitory effect of enzalutamide on P-gp substrates. The net effect of enzalutamide on apixaban and rivaroxaban plasma exposures, which are dual substrates of CYP3A4 and P-gp, was investigated using PBPK analysis. The simulation results showed a decrease in AUC for both drugs when co-administered with enzalutamide.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
(2023)
Article
Oncology
Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama, Tsuyoshi Minematsu, Kenna Shirasuna, Akira Matsuhisa, Aya Kita, Fumiko Tominaga, Kentaro Yamanaka, Masafumi Kudoh, Masao Sasamata