Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 24, Pages 5656-5659Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.10.073
Keywords
Morus alba; Pyrrole alkaloids; Morroles B-F; Pancreatic lipase; Moraceae; Mulberry
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Funding
- National Research Foundation of Korea (NFR) - Korean Government [2012-0006548, 2008-0062275]
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Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1Hpyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity. (C) 2014 Elsevier Ltd. All rights reserved.
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