Article
Immunology
Ping-Ping Sun, Dan Li, Meng Su, Qing Ren, Wen-Ping Guo, Jiang-Li Wang, Luan-Ying Du, Guang-Cheng Xie
Summary: This study investigated the effects of TLR1/2/4/6 monomers and TLR2 heterodimer on EV71 replication and innate immune activation. It was found that TLR monomers and TLR2 heterodimer inhibited EV71 replication and induced the production of IL-8. Additionally, the EV71 capsid proteins served as pathogen-associated molecular patterns for TLR monomers and TLR2 heterodimer, activating innate immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ella A. Zuiderwijk-Sick, Celine van der Putten, Raissa Timmerman, Jennifer Veth, Erica M. Pasini, Linda van Straalen, Paul van der Valk, Sandra Amor, Jeffrey J. Bajramovic
Summary: Exposure to IL-4 induces changes in the cell surface protein expression profile of primary rhesus macaque microglia and enhances their potential to induce proliferation of T cells with a regulatory signature. Additionally, IL-4 exposure broadly impairs TLR-induced cytokine production and inhibits microglial innate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tianhao Duan, Yanchun Feng, Yang Du, Changsheng Xing, Junjun Chu, Jiayu Ou, Xin Liu, Motao Zhu, Chen Qian, Bingnan Yin, Helen Y. Wang, Jun Cui, Rong-Fu Wang
Summary: This study reveals the involvement of ubiquitin-specific protease 3 (USP3) in establishing tolerance innate immune memory through non-transcriptional feedback, and its critical role in NF-kappa B signaling pathway.
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Article
Chemistry, Medicinal
Sarah S. Darwish, Po-Jen Chen, Mostafa M. Hamed, Reem A. Wagdy, Shun-Hua Chen, Ashraf H. Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Summary: This study developed new drugs that selectively inhibit the activation of NF-kappa B in macrophages, which may help treat inflammatory diseases with fewer side effects.
Article
Immunology
Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B. Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L. Shorte, Brigitte David-Watine
Summary: The LabEx Milieu Interieur (MI) project focuses on characterizing immune responses in blood samples from healthy donors, providing insights into genetic and environmental factors influencing immune variation. The study developed in vitro methods for standardized quantification of fibroblast responses, showing variability in immune phenotype among donors. These findings establish a foundation for further experimental frameworks in high-throughput screening protocols.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Juan Felipe Valdes-Lopez, Geysson J. Fernandez, Silvio Urcuqui-Inchima
Summary: The study reveals that CHIKV infection induces high levels of IL27 in MDMs, promoting pro-inflammatory and antiviral response through activation of TLR1/2-MyD88 and TLR3-TRIF signaling pathways, independent of IFN signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Endocrinology & Metabolism
Zixi Chen, Jinpeng Li, Wenjuan Xu, Xiaomei Wu, Fenfen Xiang, Xiaoxiao Li, Mengzhe Zhang, Jin Zheng, Xiangdong Kang, Rong Wu
Summary: The study found that TLR4 expression on CD14+ maternal blood monocytes was significantly higher in the third trimester compared to the first and second trimesters. Maternal serum concentrations of TLR4 and cytokines were significantly higher in the term labor group compared to the term non-labor group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhang, Lei Cao, Amy Gao, Ruiqing Ren, Liwen Yu, Qian Li, Yapeng Liu, Wenqian Qi, Yonghao Hou, Wenhai Sui, Guohai Su, Yun Zhang, Cheng Zhang, Meng Zhang
Summary: Innate immunity is the first defense line against pathogenic microorganisms, and Toll-like receptor (TLR)-mediated inflammatory responses play a crucial role. However, the regulatory mechanisms of TLRs in innate immunity are not well understood. This study showed that the E3 ligase Ring finger protein 99 (RNF99) plays a role in regulating TLR-mediated inflammatory responses and its deficiency enhances inflammatory cytokine expression in macrophages. Mechanistically, RNF99 interacts with and degrades the regulatory protein TAB2, thus regulating TLR-mediated inflammatory signaling. These findings provide new insights into TLR signal transduction and offer potential approaches for preventing bacterial infections and inflammatory diseases.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Yong Shen, Kejun Tang, Dongdong Chen, Mengying Hong, Fangfang Sun, SaiSai Wang, Yuehai Ke, Tingting Wu, Ren Sun, Jing Qian, Yushen Du
Summary: Riok3 serves as a negative regulator of antiviral innate immunity by promoting degradation of RIG-I and MDA5, thus selectively inhibiting RNA viral replication and enhancing resistance to RNA virus infections.
Article
Immunology
Morgan Simpson, Alyse Frisbee, Pankaj Kumar, Carsten Schwan, Klaus Aktories, William A. Petri
Summary: Clostridioides difficile infection (CDI) is a significant burden on the healthcare system, exacerbated by hypervirulent strains producing binary toxin (CDT). This study reveals Toll-like receptor 2 (TLR2) as the key receptor recognizing CDT and activating immune responses in mice with intact TLR2/6 signaling during CDI.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Maryam Ali Mohammadie Kojour, Tariku Tesfaye Edosa, Ho Am Jang, Maryam Keshavarz, Yong Hun Jo, Yeon Soo Han
Summary: TmSpz5 plays a defined role in the innate immunity of T. molitor by regulating AMP expression in Malpighian tubules specifically in response to Escherichia coli.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doret R. van Muilekom, Bertrand Collet, Henrike Rebl, Kristina Zlatina, Fabio Sarais, Tom Goldammer, Alexander Rebl
Summary: NF-kappa B signaling is controlled by the family of 'inhibitors of NF-kappa B' (I kappa B). Rainbow trout genome contains multiple gene copies coding for different I kappa B proteins, except for two types. The expression levels of these genes vary, suggesting their involvement in immune-regulatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Antonios Lazaridis, Eleni Gavriilaki, Stella Douma, Eugenia Gkaliagkousi
Summary: Essential hypertension is a highly heterogeneous disease with a complex etiology, where subclinical inflammation and abnormal activation of TLR signaling play crucial roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Caroline Kellogg, Valentina L. Kouznetsova, Igor F. Tsigelny
Summary: Polyomaviruses, such as SV40 and JCV, can inactivate the tumor suppressor p53 through their viral protein, LT. This study investigates the similarities between different polyomavirus LT proteins and elucidates the mechanism by which SV40 LT inactivates p53. Furthermore, the study suggests that other polyomavirus LT proteins may also have the potential to inactivate p53.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Tetsuya Saito, Nikunj M. Shukla, Fumi Sato-Kaneko, Yukiya Sako, Tadashi Hosoya, Shiyin Yao, Fitzgerald S. Lao, Karen Messer, Minya Pu, Michael Chan, Paul J. Chu, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Maripat Corr
Summary: This study identifies a new synthetic adjuvant that enhances protective immune responses from vaccines. The adjuvant acts by increasing intracellular calcium levels and nuclear translocation of the NFAT factor, promoting human immune responses.
ACS CHEMICAL BIOLOGY
(2022)
Article
Substance Abuse
Ruifeng Chen, John P. Pierce, Eric C. Leas, Tarik Benmarhnia, David R. Strong, Martha M. White, Matthew Stone, Dennis R. Trinidad, Sara B. McMenamin, Karen Messer
Summary: The use of e-cigarettes for smoking cessation in the USA did not show significant improvement in successfully quitting smoking or preventing relapse in 2017.
Article
Pharmacology & Pharmacy
Nikunj M. Shukla, Fumi Sato-Kaneko, Shiyin Yao, Minya Pu, Michael Chan, Fitzgerald S. Lao, Yukiya Sako, Tetsuya Saito, Karen Messer, Tomoko Hayashi, Howard B. Cottam, Maripat Corr, Dennis A. Carson
Summary: Extracellular vesicles play a crucial role in intercellular communication and immune regulation. Researchers have identified small molecule compounds that can enhance the immunogenicity of vaccines by increasing the release of extracellular vesicles. The compounds were screened and validated through multiple assays, leading to the discovery of potential vaccine adjuvants.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Ruifeng Chen, Kasim Hakimi, Xinlian Zhang, Karen Messer, Sandip Pravin Patel
Summary: This study investigates the associations between immune-related adverse events, blood type, and time to treatment failure in patients receiving immune checkpoint blockade. The results suggest that patients with type O blood and those who experienced immune-related adverse events may have a better treatment outcome.
Article
Gastroenterology & Hepatology
Samir Gupta, Ashley Earles, Ranier Bustamante, Olga V. Patterson, Andrew J. Gawron, Tonya R. Kaltenbach, Hanin Yassin, Mark Lamm, Shailja C. Shah, Sameer Dev Saini, Deborah A. Fisher, Maria Elena Martinez, Karen Messer, Joshua Demb, Lin Liu
Summary: In this study, the colonoscopist's adenoma detection rate (ADR) was found to be independently associated with the risk of moderate-to-high complexity adenomas. Compared to the highest quintile (ADR >47.0%), the risk of moderate-to-high complexity adenomas increased by 1.48- to 1.66-fold in the lowest 3 quintiles (ADR <19.7%-39.3%).
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Surgery
Joel M. Baumgartner, Ruifeng Chen, Karen Messer, Jula Veerapong, Kaitlyn J. Kelly, Sonia Ramamoorthy, Andrew M. Lowy
Summary: The use of Alvimopan in patients undergoing CRS-HIPEC can accelerate bowel function recovery.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Deanne Lister, Gabrielle Blizard, Mojgan Hosseini, Karen Messer, Jeremy Wellen, Claude B. Sirlin, Eric T. Ahrens
Summary: "This study explores the use of PFC nanoemulsion and F-19 MRI for detecting inflammation in a mouse model of NAFLD. The results showed significant increases in liver PFC uptake and decreases in liver fluorine density and T-1 relaxation time in HFD mice. This suggests that F-19 MRI may be a viable biomarker of liver pathology."
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Oncology
Michael J. Dennis, Assuntina G. Sacco, Yuchen Qi, Julie Bykowski, Emily Pittman, Ruifeng Chen, Karen Messer, Ezra E. W. Cohen, Kathryn A. Gold
Summary: This study aimed to evaluate the safety of the combination of CDK4/6 inhibitor palbociclib with EGFR inhibitor cetuximab and PD-L1 inhibitor avelumab in patients with R/M HNSCC. The results showed that this combination therapy was well tolerated and had a high overall response rate and median duration of response.
Article
Oncology
Jayanth S. Shankara Narayanan, Tomoko Hayashi, Suna Erdem, Sara McArdle, Herve Tiriac, Partha Ray, Minya Pu, Zbigniew Mikulski, Aaron Miller, Karen Messer, Dennis Carson, Stephen Schoenberger, Rebekah R. White
Summary: The combination of IRE and CD40Ab treatment can significantly improve the prognosis of pancreatic cancer, prolong patient survival, activate dendritic cells, identify and inhibit the progression of metastatic disease.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Yukiya Sako, Fumi Sato-Kaneko, Nikunj M. Shukla, Shiyin Yao, Masiel M. Belsuzarri, Michael Chan, Tetsuya Saito, Fitzgerald S. Lao, Helen Kong, Marina Puffer, Karen Messer, Minya Pu, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi
Summary: A small molecule compound, 634, has been found to increase the release of immunostimulatory extracellular vesicles (EVs) from dendritic cells, leading to enhanced immune response. This discovery has potential applications in vaccine development.
ACS CHEMICAL BIOLOGY
(2023)
Article
Biochemical Research Methods
Brian Kwan, Tobias Fuhrer, Daniel Montemayor, Jeffery C. C. Fink, Jiang He, Chi-yuan Hsu, Karen Messer, Robert G. G. Nelson, Minya Pu, Ana C. C. Ricardo, Hernan Rincon-Choles, Vallabh O. O. Shah, Hongping Ye, Jing Zhang, Kumar Sharma, Loki Natarajan
Summary: The growing amount of high-dimensional biomolecular data has led to the development of new statistical and computational models for risk prediction and disease classification. However, many of these methods do not provide biologically interpretable models, despite their high classification accuracy. The top-scoring pair (TSP) algorithm is an exception, as it offers accurate and robust disease classification models that are biologically interpretable. However, the standard TSP methods do not consider covariates that can heavily influence feature selection.
BMC BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Eric C. Leas, Dennis R. Trinidad, John P. Pierce, Sara B. McMenamin, Karen Messer
Summary: ObjectivesTo project cigarette consumption and set state-specific targets, this study analyzed trends in smoking behaviors and state-level data. The findings showed a decline in per capita cigarette consumption in the US since 1980, but with significant variations across states. The study also revealed growing inequality in cigarette consumption among states. Based on forecasts, only 12 states have a realistic chance of achieving target levels of consumption by 2035.
Article
Oncology
Eric T. Ahrens, Brooke M. Helfer, Charles F. O'Hanlon, Deanne R. Lister, Julie L. Bykowski, Karen Messer, Benjamin Leach, Jiawen Chen, Hongyan Xu, Gregory A. Daniels, Ezra E. W. Cohen
Summary: This study describes the use of a non-invasive biomarker to assay the apoptotic cell fraction after cell therapy infusion in a patient with head and neck squamous cell carcinoma. The results showed that the survival of the cell therapy product varies per patient, and a non-invasive assay of apoptotic cell fraction could provide insight into response and non-response mechanisms.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Andrew Tsui, Valentina L. Kouznetsova, Santosh Kesari, Milan Fiala, Igor F. Tsigelny
Summary: This article summarizes the research on the structure, function, and the impact of mutations in senataxin protein on ALS pathology. The findings suggest that senataxin and its mutations have important experimental and therapeutic potential as target for future ALS treatment and cure discoveries.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)