Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 17, Pages 4291-4293Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.07.021
Keywords
Candida albicans; Isocitrate lyase; Marine actinomycete; Streptomyces sp.; Bahamaolide A
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012R1A1A2039659]
- National Research Foundation of Korea [2012R1A1A2039659] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Bahamaolide A, a new macrocyclic lactone isolated from the culture of marine actinomycete Streptomyces sp. CNQ343, was evaluated for its inhibitory activity toward isocitrate lyase (ICL) from Candida albicans. These studies led to the identification of bahamaolide A as a potent ICL inhibitor with IC50 value of 11.82 mu M. The growth phenotype of ICL deletion mutants and quantitative RT-PCR analyses indicated that this compound inhibits the ICL mRNA expression in C albicans under C-2-carbon-utilizing conditions. The present data highlight the potential for bahamaolide A treatment of C. albicans infections via inhibition of ICL activity. (C) 2014 Elsevier Ltd. All rights reserved.
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