Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 21, Pages 5059-5062Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.09.010
Keywords
Pyruvate kinase; MRSA; Antibacterial; Indole
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Funding
- Auckland Medical Research Foundation (AMRF), New Zealand
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Methicillin-resistant Staphylococcus aureus pyruvate kinase (MRSA PK) has recently been identified as a target for development of novel antibacterial agents. Testing a series of 1,2-bis(3-indolyl)ethanes against MRSA PK has led to the discovery of a potent inhibitor that is selective over human isoforms. (C) 2014 Elsevier Ltd. All rights reserved.
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