Article
Agriculture, Multidisciplinary
Qian Wan, Jie Xu, Chengjing Zhu, Xingxing Liu, Yijun Tu, Jiachuan Lei, Jianqing Yu
Summary: In this study, 16 compounds, including 9 new amide alkaloids, were isolated from the roots of Piper longum L. These compounds exhibited better anti-inflammatory activities compared to indomethacin. Among them, five dimeric amide alkaloids showed synergistic effects with chemotherapeutic drugs against cervical cancer cells and enhanced the efficacy of paclitaxel in paclitaxel-resistant cervical cancer cells. Additionally, these dimeric amide alkaloids could promote cancer cell apoptosis through the Src/ERK/STAT3 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hui Chen, Ying Zhu, Ya-Lun Zhang, Meng-Nan Zeng, Yan-Gang Cao, Pan-Ting Sun, Bing Cao, Kun Du, Xuan Zhao, Xiao-Wei Wang, Xiao-Ke Zheng, Wei-Sheng Feng
Summary: This study isolated new neolignans and amide alkaloids from the stems of Piper kadsura, with 8 compounds showing significant neuroprotective effects against Aβ(25-35)-induced cell damage in PC12 cells, with low EC50 values. Furthermore, 3 of these compounds have the potential to reduce apoptosis and enhance autophagy.
Article
Biochemistry & Molecular Biology
Nguyen Viet Phong, Dinh Thi Nguyet Anh, Ha Yeong Chae, Seo Young Yang, Mi Jeong Kwon, Byung Sun Min, Jeong Ah Kim
Summary: Five new compounds were isolated from the fruits of Piper longum L., along with 41 known compounds. The anti-inflammatory and cytotoxic activities of all isolated compounds were evaluated, and several compounds showed significant activity. Molecular docking simulations revealed the interaction and binding mechanisms of these active metabolites with proteins related to inflammation and cancer.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Guang-Hui Gou, Liu Liu, Sardorbek Abdubakiev, Xue-Lei Xin, Haji Akber Aisa, Jun Li
Summary: This study discovered that retrofractamides A and C from Piper longum have anti-diabetic activity by activating the PI3K/AKT pathway. These compounds promote glucose consumption, uptake, glycogen synthesis, and glycolysis.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Food Science & Technology
Zhao Li, Iftikhar Ali, Jinqian Yu, Li Cui, Heng Zhu, Wenya Ma, Ge Li, Daijie Wang
Summary: An efficient off-line two-dimensional coupled with gradient high-speed counter-current chromatography (HSCCC) method was reported for preparative separation of N-alkylamides from Piper longum. Ten compounds were successfully separated and characterized by ESI-MS, H-1, and C-13 NMR spectral analysis, demonstrating the effectiveness of the method for isolating compounds from Piper species.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Oncology
Indrajeet Singh, Richa Das, Ajay Kumar
Summary: Colorectal cancer is the second most common and deadliest malignancy. Piperlonguminine, an alkaloid found in Piper longum, shows potential as a medicine for treating colorectal cancer. Network pharmacology analysis identified the targets of piperlonguminine and the colorectal cancer-related pathways.
Article
Chemistry, Applied
Lan Yu, Xiaolu Hu, Rongrong Xu, Yinying Ba, Xiaoqing Chen, Xing Wang, Bing Cao, Xia Wu
Summary: The study identified diverse amide alkaloids in different parts of Piper nigrum L., with piperine being the most abundant compound known for its neuroprotective activities.
Article
Pharmacology & Pharmacy
Bansilal R. Tiwari, Mohammed Naseeruddin Inamdar, Raha Orfali, Ahmed Alshehri, Adel Alghamdi, Moneer E. Almadani, Sultan Alshehri, Syed Imam Rabbani, Syed Mohammed Basheeruddin Asdaq
Summary: This study evaluated the efficacy of several commonly used herbal extracts against histamine and 5-HT-induced muscle spasms. The results showed that all five herbal extracts could suppress muscle contractions induced by histamine and 5-HT, with Piper longum and Piper nigrum demonstrating the best efficacy. Terminalia bellerica and Zingiber officinale also showed inhibitory effects on uterine and intestinal contractions. However, further research is needed to establish the safety and efficacy of these extracts.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ding Luo, Zhenchao Tu, Wenjing Yin, Chunlin Fan, Nenghua Chen, Zhongnan Wu, Weilong Ding, Yaolan Li, Guocai Wang, Yubo Zhang
Summary: Four new alkaloids with bis-amide matrine-type structures were isolated from the seeds of sophora alopecuroides. Compounds 3-4 showed significant anti-inflammatory effects by inhibiting key pro-inflammatory cytokines in a dose-dependent manner.
FRONTIERS IN CHEMISTRY
(2021)
Article
Environmental Sciences
S. Asha, T. C. Bessy, J. F. Joe Sherin, C. Vijil Vani, C. Vijaya Kumar, M. R. Bindhu, Shanmugam Sureshkumar, Fatimah S. Al-Khattaf, Ashraf Atef Hatamleh
Summary: Piper longum extract is used as a reducing agent in the green synthesis method to synthesize ZnO nanoparticles. This extract has an impact on the structural, optical and surface morphological properties of ZnO-NPs, specifically tuning the band gap. The nanoparticles also show different antibacterial performances and high degradation efficiency of dyes under UV light irradiation. The synthetic nanopowders have important potential for various biochemical and environmental applications.
ENVIRONMENTAL RESEARCH
(2022)
Article
Plant Sciences
Krissie D. Soares, Sergio A. L. Bordignon, Miriam A. Apel
Summary: This study chemically characterized the essential oils of Piper gaudichaudianum and Piper mikanianum, and evaluated their neutrophil antichemotactic activity. The results showed that these essential oils have a strong ability to inhibit neutrophil chemotaxis, indicating their potential anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Armando A. Roca A. Suarez, Enkhtuul Batbold, Birke Bartosch, Naranjargal Dashdorj, Barbara Testoni, Fabien Zoulim
Summary: Hepatitis delta virus (HDV) is a satellite RNA virus that requires hepatitis B virus (HBV) for replication. Co-infection with HDV/HBV leads to faster disease progression compared to HBV mono-infection. Developing antiviral therapies targeting HDV is crucial. Evaluating promising HDV-specific drugs and combination therapies, as well as exploring anti-HBV drugs with potential effects against HDV, are key areas of research.
LIVER INTERNATIONAL
(2023)
Article
Plant Sciences
Avinash Sanap, Kalpana Joshi, Tejas Shah, Girish Tillu, Ramesh Bhonde
Summary: The study showed that Piper longum L. fruit extract significantly increased proliferation of WJMSCs and enhanced Ca2+ accumulation and matrix mineralization, along with promoting alkaline phosphatase (ALP) activity and the expression of key gene mRNAs. This suggests that the fruit extract can enhance osteogenic differentiation of WJMSCs, potentially serving as an anti-osteoporotic agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Chun-Yue Liu, Yong-Fu Lu, Si-Xuan Liu, Yong-Fu Li, Yan Dong, Chang Li, Yue-Hu Pei
Summary: Two new compounds were isolated from Piper macropodum and their structures were determined through extensive spectroscopic analysis. The structures of the remaining compounds were identified by comparing NMR spectroscopic data with literature reports. The compounds exhibited significant inhibitory effects on NO release from LPS-induced RAW264.7 cells.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Applied
Jie Xu, Yulu Wei, Qingyu Liu, Xingxing Liu, Chengjing Zhu, Yijun Tu, Jiachuan Lei, Jianqing Yu
Summary: This research investigated the bioactive alkaloids of the stems of Piper nigrum and found eight new dimeric amide alkaloids and eight known compounds. All compounds showed excellent anti-inflammatory activity, and the dimeric amide alkaloids enhanced the anticancer effect of paclitaxel against cervical cancer cells. These results highlight the potential of P. nigrum stems as a sustainable source of bioactive alkaloids for development and utilization in the food and health industries.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)