Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 10, Pages 3007-3012Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.03.029
Keywords
alpha-Amylase; Diabetes; Enterodiol; Enterolactone; Flaxseed; alpha-Glucosidase; Secoisolariciresinol (diglucoside)
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Funding
- Region Centre
- Conseil General d'Eure et Loir
- 'Ligue Contre le Cancer, Comite d'Eure et Loir'
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Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is by far the richest source of the dietary lignans (i.e., secoisolariciresinol diglucoside) which have been shown to delay the development of T2DM in animal models. Herein, we propose the first evidences for a mechanism of action involving the inhibition of the pancreatic alpha-amylase (EC 3.2.1.1) by flaxseed-derived lignans that could therefore constitute a promising nutraceutical for the prevention and the treatment of T2DM. (C) 2013 Elsevier Ltd. All rights reserved.
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