Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 24, Pages 7465-7470Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.10.043
Keywords
Allium victorialis var. platyphyllum; Liliaceae; Allivictoside A-H; Anti-neuroinflammatory effect
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0007162]
- National Research Foundation of Korea [2010-0007162] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Eight new flavonoid glycosides, named allivictoside A-H (1-8), together with twelve known flavonoids (9-20) were isolated from the leaves of Allium victorialis var. platyphyllum. The structures of 1-8 were determined by chemical and spectroscopic methods, including 1D, 2D NMR analyses and HR-MS. To evaluate the anti-neuroinflammatory activities of all isolates, we measured the secreted nitric oxide levels in murine microglia BV-2 cells stimulated by lipopolysaccharide. In this study, compounds 2, 6, 10, and 18 significantly inhibited nitric oxide production (IC50 values of 20.67, 20.42, 21.48 and 19.80 mu M, respectively) without cell toxicity. Therefore, we suggest that allivictoside B (2) and F (6), 3-O-beta-D-glucosyl-7-O-beta-D-(2-O-feruloyl) glucosylkaempferol (10) and quercetin 3-O-beta-D-glucopyranoside (18) may be considered as candidates for the treatment of diseases associated with neuroinflammation. (C) 2012 Elsevier Ltd. All rights reserved.
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