Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 3, Pages 1019-1022Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.12.031
Keywords
Thalidomide; TNF-alpha; IL-6; 1H-Imidazo[1,5-a]indole-dione; Dihydro-thiadiazolo[2,3-b]-isoquinolinone-dioxide; 1H-Pyrrolo-[2,3-b]pyridine
Categories
Funding
- Laboratory of Organic and Therapeutic Chemistry
- INCa (Institut National du Cancer
- MAb IMPACT network)
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Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Among these compounds, two analogues containing sulfonyl group displayed interesting downregulation of TNF-alpha and IL-6 production. (C) 2010 Elsevier Ltd. All rights reserved.
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