Article
Chemistry, Organic
Maria Miguel-Gordo, Maggie M. Reddy, Pilar Sanchez, Jordan J. Buckley, Thomas A. Mackenzie, Laurence K. Jennings, Fernando Reyes, Kevin Calabro, Olivier P. Thomas
Summary: In this study, ten new nitrogenous bisabolene derivatives were isolated from a sponge collected from the Futuna Islands. These compounds include monomeric theonellin formamide analogues with unusual oxidised linear chains and the first isocyanide/formamide dimeric and cyclised bisabolenes. The structure elucidation involved various analysis methods, and a biosynthetic hypothesis was proposed. The antimicrobial and antitumoral activity of these compounds were evaluated, and the trans-dimer theonellin isocyanide was shown to exhibit potent and selective antifungal activity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Chemistry, Physical
Andras Gy Nemeth, Peter Abranyi-Balogh
Summary: This review discusses the best practices for the synthesis of ITCs using elemental sulfur, including the in situ generation of thiocarbonyl surrogates and the reaction pathways of carbenes and amines to form isocyanides, which further react with sulfur to generate ITCs. Additionally, it reveals the existence of two previously overlooked and uninvestigated mechanistic pathways in the catalyst-free reaction of isocyanides and sulfur.
Review
Chemistry, Organic
Adrian Lavios, Amparo Sanz-Marco, Carlos Vila, Gonzalo Blay, Jose R. Pedro
Summary: The spirocyclic motif is widely found in natural products, chiral ligands, and pharmacologically active compounds. The formal [3+2] cycloaddition reaction of isothiocyanates or isocyanides with cyclic compounds has been developed for the enantioselective synthesis of aza-spirocyclic compounds, with organocatalysis playing a key role in these reactions. The synthesis of spirooxindoles using this methodology has received particular attention, highlighting the importance of the structure of the dipolarophiles and the isothiocyanate and isocyanide dipoles.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhipeng Guan, Shuxiang Zhu, Siyuan Wang, Huamin Wang, Siyuan Wang, Xingxing Zhong, Faxiang Bu, Hengjiang Cong, Aiwen Lei
Summary: An unprecedented electrochemical oxidative carbon-atom difunctionalization of isocyanides has been developed, providing a series of novel multisubstituted imino sulfide ethers. This metal-free and external oxidant-free method shows high stereoselectivities, excellent functional-group tolerance, and good efficiency for large-scale synthesis, enabling further derivatization of the products.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chayma Ben Maamer, Rihab Dridi, Malek Lahmar, Mohamed Ali Tabarki, Mariem Jobran, Sami Sahtel, Mohamed Faouzi Zid, Hadda Imene Ouzari, Emmanuel Vrancken, Rafaa Besbes
Summary: Cis-2-iminothiazolidines and cis-thiazolidine-2-iminiumtetrafluoroborates were successfully synthesized from trans-N-alkyl aziridine-2-carboxylates and phenyl/alkyl isothiocyanates mediated by zinc tetrafluoroborate in refluxing DCE. The reactions showed complete regio- and stereoselectivity, yielding moderate to good amounts (35-82%) with a wide range of substrates.
Article
Biochemistry & Molecular Biology
Norikazu Koyasu, Fuminori Hyodo, Ryota Iwasaki, Hinako Eto, Abdelazim Elsayed Elhelaly, Hiroyuki Tomita, Shinichi Shoda, Masaki Takasu, Takashi Mori, Masaharu Murata, Akira Hara, Yoshifumi Noda, Hiroki Kato, Masayuki Matsuo
Summary: In this study, the usefulness of spatiotemporal redox status as an early imaging biomarker of tumor response after irradiation using in vivo DNP-MRI was demonstrated. The results showed that in vivo DNP-MRI/CmP allowed faster and earlier visualization of tumor redox status responses compared to the verification of morphological changes observed with 1.5 T MRI and cancer metabolism obtained by hyperpolarized C-13 pyruvate MRS. The early assessment of redox status alterations with in vivo DNP-MRI/CmP probe may provide efficient information regarding the effectiveness of subsequent radiation treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Pankaj Kumar, Jaswinder Kaur, Sumeeta Kumari, Sakshi Paliwal, Shiwani Berry, Anil Kumar Pinnaka, Aman Bhalla
Summary: A novel synthetic method was developed to synthesize cis-3-aroyl-urea-beta-lactams and cis-3-aroyl-thiourea-beta-lactams, and their antibacterial and antifungal activities were evaluated. Compound 8e exhibited potent antibacterial activity against various bacterial strains, while compounds 8d and 8e showed promising antifungal properties. Molecular docking analysis provided additional support for the observed activities of compound 8e.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hao Fan, Wenda Wu, Mahalingam Ravivarma, Hongbin Li, Bo Hu, Jiafeng Lei, Yangyang Feng, Xiaohua Sun, Jiangxuan Song, Tianbiao Leo Liu
Summary: In this study, a stable organic catholyte was developed for aqueous organic redox flow batteries (AORFBs) through rational molecular engineering. The organic catholyte exhibited a long cycle-life and a low capacity fade rate, indicating excellent stability.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yunfan Qiu, Hannah J. Eckvahl, Asif Equbal, Matthew D. Krzyaniak, Michael R. Wasielewski
Summary: The coherence times of molecular spin qubits and qudits are influenced by molecular structure. By tailoring the molecular structure through selective deuteration and eliminating intramolecular motion, the coherence times can be significantly enhanced.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Jakub Cedrowski, Kajetan Dabrowa, Pawel Przybylski, Agnieszka Krogul-Sobczak, Grzegorz Litwinienko
Summary: SFN and ERN, two isothiocyanates, exhibit chemopreventive and anticancer activities by modulating cellular redox status and showing significant antioxidant effects at elevated temperatures. These effects are attributed to their ability to induce cytoprotective enzymes and participate in radical trapping during lipid oxidation.
Review
Chemistry, Inorganic & Nuclear
Jonghyeon Lee, Seungpyo Hong, Yoonji Heo, Houng Kang, Min Kim
Summary: Combining the chemistry of TEMPO with the properties of MOFs and COFs offers potential for significant advancements in catalytic applications, with improved recyclability and selectivity. This synergy is being explored as a promising approach in catalytic reactions using functional porous materials.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Natalie C. Dwulet, Zeinab Chahine, Karine G. Le Roch, Christopher D. Vanderwal
Summary: We have successfully synthesized the rare isocyanoterpene natural product isoneoamphilectane and its two unnatural diastereomers. Our initial hypothesis about a misassignment in the structure's relative configuration led us to target two less-strained stereoisomers, but they did not match the spectroscopic data of isoneoamphilectane. We then embarked on a challenging synthesis of the originally proposed strained structure, guided by computational analyses to control stereochemistry.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Man Wang, Gan Liang, Yunhao Wang, Tao Fan, Baoling Yuan, Mingxian Liu, Ying Yin, Liangchun Li
Summary: Two highly efficient metal-organic framework catalysts have been synthesized through solvothermal reactions, with highly active nitroxyl catalytic sites for efficient oxidation reactions of alcohols and benzyl compounds under mild conditions. The system is environmentally friendly and sustainable with a simple work-up procedure.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Hao Fan, Bo Hu, Hongbin Li, Mahalingam Ravivarma, Yangyang Feng, Jiangxuan Song
Summary: We report a stable catholyte MIAcNH-TEMPO for aqueous zinc hybrid flow batteries (AZHFBs) with high stability and long-lasting capacity. By incorporating double-conjugate substituents, the electron density of TEMPO can be delocalized, resulting in the stabilization of its radical and oxoammonium forms and avoiding side reactions. The MIAcNH-TEMPO/Zn AZHFB exhibits excellent stability with a constant capacity retention of 99.95% per day over 16.7 days at high concentration catholyte and high current density.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Vladimir A. Dodonov, Olga A. Kushnerova, Roman Rumyantsev, Alexander S. Novikov, Vladimir K. Osmanov, Igor L. Fedushkin
Summary: Heterocumulenes Se =CNR (R = C6H4OMe-2, C6H4Me-2) undergo cycloaddition to form cycloadducts derived from a sodium metallacycle. Comparative reaction shows that the magnesium cycloadducts decompose rapidly at room temperature.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Jerzy Zakrzewski, Bogumila Huras, Anna Kielczewska
SYNTHESIS-STUTTGART
(2016)
Article
Chemistry, Inorganic & Nuclear
Bogumila Huras, Jerzy Zakrzewski, Anna Kielczewska, Maria Krawczyk
JOURNAL OF FLUORINE CHEMISTRY
(2017)
Article
Chemistry, Organic
Karolina Jasiak, Agnieszka Kudelko, Monika Wroblowska, Anna Biernasiuk, Anna Malm, Maria Krawczyk
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Bogumila Huras, Jerzy Zakrzewski, Maria Krawczyk, Danuta Bombinska, Anna Cieniecka-Roslonkiewicz, Alicja Michalczyk
MEDICINAL CHEMISTRY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Miroslaw Gucma, Elzbieta Romanowska, Wieslaw Marek Golebiewski, Maria Krawczyk
JOURNAL OF FOOD BIOCHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Jerzy Zakrzewski, Bogumila Huras, Anna Kielczewska, Maria Krawczyk
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Jerzy Zakrzewski, Bogumila Huras, Anna Kielczewska, Maria Krawczyk, Jaroslaw Hupko, Katarzyna Jaszczuk
Article
Chemistry, Inorganic & Nuclear
Bogumila Huras, Jerzy Zakrzewski, Krzysztof Zelechowski, Anna Kielczewska, Maria Krawczyk, Jaroslaw Hupko, Katarzyna Jaszczuk
Summary: The fluorine analogs of dicamba and tricamba herbicides were synthesized and their herbicide activities were compared with the activities of conventional dicamba and tricamba herbicides.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Krzysztof Zelechowski, Jerzy Zakrzewski, Bogumila Huras, Anna Kielczewska, Maria Krawczyk, Alicja Katarzyna Michalczyk, Jaroslaw Hupko, Katarzyna Jaszczuk
Summary: A new method for modifying carboxylic groups in phenoxyacetic herbicides using the Passerini reaction has been proposed. The synthesized Passerini adducts showed excellent herbicidal and fungistatic activities with high yields.
Article
Chemistry, Multidisciplinary
Krzysztof Zelechowski, Miroslaw Gucma, W. Marek Golebiewski, Maria Krawczyk, Alicja Katarzyna Michalczyk
ACTA CHIMICA SLOVENICA
(2020)
Article
Chemistry, Applied
Alicja Wodnicka, Elzbieta Huzar, Malgorzata Dzieciol, Maria Krawczyk
POLISH JOURNAL OF CHEMICAL TECHNOLOGY
(2019)
Article
Chemistry, Applied
Alicja Wodnicka, Elzbieta Huzar, Maria Krawczyk, Halina Kwiecien
POLISH JOURNAL OF CHEMICAL TECHNOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Miroslaw Gucma, W. Marek Golebiewski, Krzysztof Zelechowski, Maria Krawczyk
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)