Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 21, Pages 6297-6300Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.08.120
Keywords
YC-1; HIF-1 alpha; SAR (structure-activity relationship); Hypoxia; Anti-cancer agent
Categories
Funding
- National Research Foundation of Korea (NRF)
- Korean Government (MEST) [20100028431]
- Research Institute of Pharmaceutical Science, Seoul National University
Ask authors/readers for more resources
Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available