Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 8, Pages 2566-2571Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.02.085
Keywords
Viburnum sieboldii; Caprifoliaceae; Diterpenoid; Vibsane; Neurite outgrowth-promoting activity; PC12 cells; NGF
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [18032085, 19790027]
- Grants-in-Aid for Scientific Research [22590029, 18032085, 19790027] Funding Source: KAKEN
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Six new vibsane-type diterpenoids, named neovibsanin O (1), neovibsanin M (2), neovibsanin L (3), (8Z)neovibsanin M (4), 15-O-methylvibsanin H (5), and 5-epi-15-O-methylvibsanin H (6), were isolated from the leaves of Viburnum sieboldii by bioassay-guided fractionation using NGF-differentiated PC12 cells. The structures of 1-6 were established by analyzing their spectroscopic data and comparing their NMR data with those of previously reported vibsane-type diterpenoids. Compounds 3 and 4, and the known vibsane-type diterpenoids neovibsanins A (7) and B (8) significantly enhanced the neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 20 to 40 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
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