4.5 Article

Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 23, Pages 6920-6924

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.09.137

Keywords

omega-Substituted acetophenone azines; Vilsmeier's reagent; Pyrazole derivatives; Microwave irradiation; Antimycobacterial activity

Funding

  1. Madurai Kamaraj University, Madurai

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Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the formation of the products. The antimycobacterial activity of the isomeric compounds has been tested against Mycobacterium tuberculosis (MTB). (C) 2010 Elsevier Ltd. All rights reserved.

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