Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats

Title
Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats
Authors
Keywords
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Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 21, Pages 6262-6267
Publisher
Elsevier BV
Online
2010-08-22
DOI
10.1016/j.bmcl.2010.08.095

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