4.5 Article

2-, 3-, and 4-(1-Oxo-1H-2,3-dihydroisoindol-2-yl)benzoic acids and their corresponding organotin carboxylates: Synthesis, characterization, fluorescent, and biological activities

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 19, Pages 5649-5652

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.08.034

Keywords

Organotin carboxylate; Synthesis; Antibacterial activity; Antifungal activity; Fluorescence

Funding

  1. Main Precise Instrument of Hunan University [104080, 104082]

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Three novel organotin complexes with general formula Sn(OH)(bz)(2)L (bz = benzyl, HL = 2-, 3-, or 4-(1-oxo-1H-2,3-dihydroisoindol-2-yl)benzoic acid) and one of their ligands were prepared and characterized. In vitro antifungal and antibacterial activities of these complexes and ligands were investigated with the representative strains of Candida albicans, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Their fluorescence properties have also been discussed. (C) 2010 Elsevier Ltd. All rights reserved.

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