Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 18, Pages 5505-5509Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.05.060
Keywords
Combi-triazenes; EGFR; HER2; Quinazoline
Categories
Funding
- Canadian Institutes of Health Research (CHIR) [FRN 49440]
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The monoalkyltriazene moiety lends itself well to the design of combi-molecules. However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position. The synthesis and biological activities of these novel N-carbamyl triazenes are described. (C) 2009 Elsevier Ltd. All rights reserved.
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