Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 12, Pages 3259-3263Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.094
Keywords
Tetrac; Esterification; Silylation; HPLC; Angiogenesis; Nanopharmaceutical technology
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Funding
- Charitable Leadership Foundation
- Medical Technology Acceleration Program
- Pharmaceutical Research Institute
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Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity. (C) 2009 Published by Elsevier Ltd.
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