Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 24, Pages 6926-6930Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.070
Keywords
Hepatitis C virus; Core protein; Inverse electron demand Diels-Alder reaction; Indoline; Protein-protein interaction
Categories
Funding
- The Scripps Research Institute-Scripps Florida [20,383]
- Factor Foundation
- NIGMS CMLD [P50 GM067041, P41 GM086180]
- National Science Foundation [CHE 0619339, CHE 0443618]
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New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells. (C) 2009 Elsevier Ltd. All rights reserved.
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