Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 18, Pages 5452-5457Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.07.095
Keywords
Cytometry; Malarial; Drug discovery
Categories
Funding
- NIH [AI52312]
- CWRU Center for Global Health and Diseases
- National Institute on Drug Abuse [DA-03816]
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A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 mu M) overall and ring stage in vitro antimalarial activity. (C) 2009 Elsevier Ltd. All rights reserved.
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