Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 6, Pages 1614-1617Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.023
Keywords
Unnatural amino acid; Ferrocene; Nuclease; DNA cleavage
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Funding
- Dickinson College Research and Development
- Howard Hughes Medical Institute
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The nucleolytic activity of an unnatural ferrocenyl amino acid can be significantly enhanced under reducing or Fenton conditions while exploiting different mechanisms of DNA cleavage. In addition, results from high resolution electrophoresis indicate that the ferrocenyl amino acid exhibits non-sequence specific cleavage of the DNA backbone. (C) 2009 Elsevier Ltd. All rights reserved.
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