Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 1, Pages 184-187Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.10.102
Keywords
synthesis; aminoalcohols; diamines; sphingosine; SAR; in vitro assays; Leishmania; Trypanosoma
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A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the mu M or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses. (C) 2007 Elsevier Ltd. All rights reserved.
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