Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: Synthesis, spectral, antimicrobial, and DNA interaction approach

Five-coordinated oxovanadium(IV) complexes with ciprofloxacin and various uninegative bidentate amino acids have been prepared. The structure of complexes has been investigated using spectral, physicochemical, mass spectroscopy, and elemental analyses. The antimicrobial activities (MIC) of the complexes, ligands, metal salt, and some standard drugs have been evaluated using the doubling dilution technique against Staphylococcus aureus, Baccilus subtilis, Serratia marcescens (Gram-positive), and Pseudomonas aeruginosa, and Escherichia coli (Gram-negative) bacteria. The result shows the significant increase in the antibacterial activity of the ligand, metal, and ciprofloxacin on complexation. The interaction of the complexes with pBR322 DNA has been investigated using spectroscopic, gel electrophoresis, and viscometric techniques. This shows that the complexes can bind to pBR322 DNA by the intercalative mode. The superoxide dismutase-like activity of the complexes has been determined. (C) 2008 Elsevier Ltd. All rights reserved.