Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 18, Pages 4940-4943Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.08.041
Keywords
reboxetine; stereoselective synthesis; SPECT; imaging; noradrenaline; transporter
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Funding
- EPSRC
- BBSRC
- Medical Research Scotland
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A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT. (C) 2008 Elsevier Ltd. All rights reserved.
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