Article
Energy & Fuels
Rongshuan Xu, Ping Song, Dalin Zhang, Wenxi Tian, Suizheng Qiu, Guanghui H. Su
Summary: This study developed a numerical analysis code called COSFIAS to investigate the flow instability of parallel channels in a sodium heated OTSG, validated experimental data, and drew conclusions: decreasing water pressure increases heat transfer power and destabilizes the system; sodium heated condition is more stable compared to uniform heating condition; inlet subcooling in different regions affects the stability of the parallel channels system.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Chemistry, Analytical
Guangliang Song, Yuwei Song, Senqiang Zhu, Jinfeng Ji, Rui Liu, Hongjun Zhu
Summary: The newly synthesized bis-photochromic molecules display significant pH response characteristics and potential for use as pH probes in acetonitrile solutions and PMMA membranes. Under ultraviolet light, these compounds exhibit photochromism and 'turn-off' fluorescence properties, possibly due to photoisomerization of the 4,5-diarylimidazole units.
Article
Mechanics
B. Wang, R. Ayats, A. Meseguer, F. Marques
Summary: In this paper, the stability and dynamical relevance of different types of flows between orthogonally stretching parallel plates are explored. It is found that the Stokesian flow is stable, while other flow solutions are unstable. When both plates shrink, a Hopf bifurcation occurs leading to stable time-periodic regimes. Additionally, quasiperiodic flows and chaotic dynamics are observed, but chaotic dynamics is rare.
Article
Chemistry, Multidisciplinary
Dengqi Xue, Yani Liu, Yilin Zheng, Heling Niu, Liying Dong, Xiangshuo Ouyang, Siyu Song, Denggao Zhang, Qianwei Ge, Kewei Wang, Liming Shao
Summary: Three novel series of alpha-aminoamides derivatives were synthesized based on ralfinamide, and their inhibitory activities against Nav1.7 were evaluated. The most potent compound 19h exhibited significantly higher activity than ralfinamide, and the structure-activity relationship investigation provided a strategy for improving the Nav1.7 inhibition of ralfinamide analogues.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Xiangshuo Ouyang, Min Su, Dengqi Xue, Liying Dong, Heling Niu, Wei Li, Yani Liu, KeWei Wang, Liming Shao
Summary: Chronic pain severely impacts quality of life and requires effective treatments. This study designed, synthesized, and evaluated a series of acyl sulfonamide derivatives targeting NaV1.7 for their antinociceptive activities. Among them, compound 36c was identified as a selective and potent NaV1.7 inhibitor in vitro and showed antinociceptive effects in vivo. The discovery of 36c provides new insights into selective NaV1.7 inhibitors and potential pain therapies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Molly O'Reilly, Laura C. Sommerfeld, C. O'Shea, S. Broadway-Stringer, S. Andaleeb, J. S. Reyat, S. N. Kabir, D. Stastny, A. Malinova, D. Delbue, L. Fortmueller, K. Gehmlich, D. Pavlovic, B. Skryabin, A. P. Holmes, P. Kirchhof, L. Fabritz
Summary: This study found that the point mutation M1875T in the SCN5A gene is associated with familial AF. A new mouse model was used to show that this mutation causes gain-of-function of the cardiac sodium channel, resulting in increased atrial excitability.
Review
Biochemistry & Molecular Biology
Cedric Vallee, Brendan Howlin, Rebecca Lewis
Summary: The Epithelial Sodium Channel/Degenerin (ENaC/DEG) family is a superfamily of sodium-selective channels with high homology in the pore region, playing important physiological roles in various animal species. The G/SxS selectivity filter and other conserved residues are crucial for ion selectivity, with different residues involved in ion permeability depending on the ion type. This review highlights new perspectives for further exploration of ion selectivity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zunhua Yang, Yuanying Fang, Jae-Min Kim, Kyung-Tae Lee, Haeil Park
Summary: A series of halogenated 1,5-diarylimidazole compounds were synthesized and evaluated for their inhibitory effects on PGE(2) production. 4-halogenated 5-aryl-1-(4-methylsulfonylphenyl)imidazoles showed strong inhibitory activities regardless of halogen type, with compounds 3 and 13 exhibiting the best results.
Review
Biochemistry & Molecular Biology
Xin Wu, Liang Hong
Summary: Calmodulin (CaM) is a small protein that serves as a ubiquitous signal transducer, regulating neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. Mutations in CaM-binding IQ domain can lead to various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jing-Jing Liu, Katherine W. Eyring, Gabriele M. Koenig, Evi Kostenis, Richard W. Tsien
Summary: Oxytocin modulates ion channels in CA2 pyramidal neurons, increasing responsiveness to synaptic inputs and promoting rhythmic firing. These mechanisms deepen our understanding of oxytocin's role in promoting social memory and cognitive control.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Chemistry, Physical
A. Hamrang, M. Abdollahzadeh, A. Moradi Bilondi, F. Bagherighajari, S. M. Rahgoshay, J. C. Pascoa
Summary: This study compares the performance of a PEMFC with conventional parallel serpentine flow fields and parallel serpentine-baffled flow fields. The results show that the PSBFF design can significantly improve cell performance, especially at higher pressure, temperature, and stoichiometric ratio.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Food Science & Technology
Leisiane Pereira Marques, Artur Santos-Miranda, Julliane Vasconcelos Joviano-Santos, Jorge Lucas Teixeira-Fonseca, Fabiana da Silva Alcantara, Jaqueline Oliveira Sarmento, Danilo Roman-Campos
Summary: The fungicide Tebuconazole affects the sodium current of human cardiac sodium channels by reducing its amplitude in a concentration- and voltage-dependent manner. It alters the inactivation properties and recovery kinetics of the current, and enhances closed-state inactivation and use-dependent block. Furthermore, Tebuconazole reduces the increase in late sodium current induced by another insecticide. These findings suggest a new mechanism of cardiotoxicity attributed to Tebuconazole.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Physiology
Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Summary: The study demonstrates that targeted activation of Gs signaling exclusively in renal principal cells (PC) is sufficient to increase ENaC activity and decrease urinary sodium excretion in live animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Infectious Diseases
Emma Reid, Rinki Michelle Deb, Asgar Ali, Rudra Pratap Singh, Prabhas Kumar Mishra, Josephine Shepherd, Anand Mohan Singh, Aakanksha Bharti, Chandramani Singh, Sadhana Sharma, Michael Coleman, David Weetman
Summary: Molecular surveillance of resistance is crucial in vector borne disease control programmes that use insecticides. The study monitored the frequency of resistance-associated genotypes in India for five years and found a significant increase between 2017 and 2018, followed by relative stability and some reversion in 2021. The study highlights the importance of continued monitoring and improvement of spray quality in order to effectively control vector-borne diseases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Kun Tong, Ruotian Zhang, Fengzhi Ren, Tao Zhang, Junlin He, Jingchao Cheng, Zixing Yu, Fengxia Ren, Yatong Zhang, Weiguo Shi
Summary: Novel alpha-aminoamide derivatives containing different benzoheterocyclic moieties were synthesized and evaluated for their potential as voltage-gated sodium ion channel blockers for pain treatment. Compounds 6a, 6e, and 6f displayed stronger in vivo analgesic activity than ralfinamide and also showed potent in vitro anti-Na(v)1.7 and anti-Na(v)1.8 activity, suggesting their potential as new leads for the development of analgesic drugs targeting pain-related Na-v channels.
Article
Biochemistry & Molecular Biology
Alessio Malacrida, Mirko Rivara, Alessandro Di Domizio, Giacomo Cislaghi, Mariarosaria Miloso, Valentina Zuliani, Gabriella Nicolini
BIOORGANIC & MEDICINAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Wout J. Weuring, Sakshi Singh, Linda Volkers, Martin B. Rook, Ruben H. van't Slot, Marjolein Bosma, Marco Inserra, Irina Vetter, Nanda M. Verhoeven-Duif, Kees P. J. Braun, Mirko Rivara, Bobby P. C. Koeleman
Article
Chemistry, Organic
Saurabh K. Tiwari, Km Neha Shivhare, Manoj K. Patel, Vikas Yadav, Mohd Nazeef, I. R. Siddiqui
Summary: We report an eco-friendly and facile strategy for the synthesis of 1,4-dihydropyridine (1,4-DHP) derivatives through a one pot multi-component Hantzsch reaction using glycerol as a promoting medium. The protocol offers a greener, economical, and expeditious synthesis of biologically significant 1,4-DHPs with moderate to excellent yields under metal-free mild reaction conditions. The additional advantages include operational simplicity, cost effectiveness, and reusability with the avoidance of hazardous volatile solvents.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Manjula Singh, Laxmi Kant Sharma, Rahul Dubey, Manoj Kumar Patel, Ved Prakash, Rana Krishna Pal Singh
Review
Clinical Neurology
Eric R. Wengert, Manoj K. Patel
Summary: Voltage-gated sodium channels play a crucial role in generating action potentials in the nervous system, with a persistent sodium current contributing to normal neuronal function but potentially playing a pathogenic role in epilepsy. Targeting the persistent sodium current may hold promise for developing novel anti-seizure medication strategies.
Article
Clinical Neurology
Ian C. Wenker, Frida A. Teran, Eric R. Wengert, Pravin K. Wagley, Payal S. Panchal, Elizabeth A. Blizzard, Priyanka Saraf, Jacy L. Wagnon, Howard P. Goodkin, Miriam H. Meisler, George B. Richerson, Manoj K. Patel
Summary: The study revealed that apnea coincident with the tonic phase of a seizure, and subsequent failure to resume breathing, are determining events that cause seizure-induced death in Scn8a mutant mice.
ANNALS OF NEUROLOGY
(2021)
Article
Neurosciences
Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel
Summary: This study demonstrates that mice harboring an Scn8a allele with a patient-derived mutation are susceptible to audiogenic seizures and seizure-induced death, providing a new model for studying seizure-induced death. Activation of adrenergic receptors is necessary and sufficient for recovery of breathing and prevention of seizure-induced death in this novel audiogenic seizure-induced death model.
FRONTIERS IN NEUROSCIENCE
(2021)
Editorial Material
Clinical Neurology
Eric R. Wengert, Manoj K. Patel
Article
Pharmacology & Pharmacy
Ankita Sharma, Shardulya Shukla, Abul Quasim, Manoj Kumar Patel, Raj Kumar, Om Prakash Chaurasia, Shweta Saxena
Summary: This study developed an in vitro regeneration protocol for Rubia cordifolia using nodal and leaf explants, and compared the phytochemical profiles of in vitro grown leaves (RUML) and roots (RUMR). The results showed that both leaves and roots contain medicinal compounds, with 8 compounds commonly present in both extracts.
ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL
(2021)
Article
Biology
Alessio Malacrida, Alessandro Di Domizio, Angela Bentivegna, Giacomo Cislaghi, Eleonora Messuti, Silvia Maria Tabano, Carlo Giussani, Valentina Zuliani, Mirko Rivara, Gabriella Nicolini
Summary: Glioblastoma (GBM) is an aggressive brain tumor with a poor prognosis. Surgical resection followed by radiotherapy and temozolomide (TMZ) treatment represents the standard strategy for GBM. However, tumor recurrences and TMZ resistance are common, requiring the development of new pharmacological strategies. This study discovered that MV1035, an imidazobenzoxazin-5-thione, can reduce migration and invasiveness of GBM cells and has a synergistic effect when used in combination with TMZ.
Article
Biochemistry & Molecular Biology
Michele Massa, Mirko Rivara, Gaetano Donofrio, Luigi Cristofolini, Erica Peracchia, Carlotta Compari, Franco Bacciottini, Davide Orsi, Valentina Franceschi, Emilia Fisicaro
Summary: This paper evaluates the gene delivery ability of newly synthesized gemini bis-pyridinium surfactants and compares them with compounds of different lengths. The results suggest that these surfactants could be a valuable tool for gene delivery purposes, but their performance depends on the spacer length and structure in solution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Linda Benincasa, Eleonora Molesti, Alessandro Manenti, Emanuele Montomoli, Alessio Malacrida, Valentina Zuliani, Mirko Rivara, Gabriella Nicolini, Alessandro Di Domizio
Summary: ALKBH5 inhibitors can reduce the replication of SARS-CoV-2 through an interaction with host cells, potentially providing a new strategy for antiviral treatment. This finding paves the way for the development of molecules that are less susceptible to drug resistance.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Engineering, Electrical & Electronic
Aarti Chauhan, Manoj Kumar Patel, Shilpa Chaudhary, Manoj Kumar Nayak, Surender Singh Saini, Pratap Pullammanappallil, Nadarajah Manivannan, Geoffrey Robert Mitchell, Wamadeva Balachandran
Summary: This research aims to evaluate the chargeability of sodium hypochlorite and an air-assisted electrostatic disinfection device. Five different surfaces were examined to assess efficacy, survival time, off-target losses, spray coverage, and disinfectant consumption. The results showed that sodium hypochlorite achieved a significant charge-to-mass ratio of 2.43 mC/kg at specific conditions and effectively eliminated Pseudomonas aeruginosa, Clostridium perfringens, and Bacteriophage MS2 colonies at a concentration of 1000 mg/L.
JOURNAL OF ELECTROSTATICS
(2023)
Article
Biochemistry & Molecular Biology
Michele Massa, Mirko Rivara, Thelma A. Pertinhez, Carlotta Compari, Gaetano Donofrio, Luigi Cristofolini, Davide Orsi, Valentina Franceschi, Emilia Fisicaro
Summary: The development of efficient and safe non-viral vectors is crucial for gene-based medicine. This study shows that the length of the hydrophobic chain does not significantly affect gene delivery, while the length of the spacer plays a key role in gene transfer capacity.
Article
Multidisciplinary Sciences
Aarti Chauhan, Manoj Kumar Patel, Manoj Kumar Nayak, Surender Singh Saini
Summary: Electrostatic spraying is an effective method for disinfecting surfaces to prevent transmission of SARS-CoV-2. The design and performance of a motorized pressure-nozzle based handheld electrostatic disinfection device were optimized, and the chargeability of various disinfectants was investigated.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)