Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 2, Pages 700-703Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.11.055
Keywords
glyconanoparticles; biosensor; Shiga toxin
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Funding
- NIEHS NIH HHS [R43 ES016392-01, R43 ES016392-02] Funding Source: Medline
- NINDS NIH HHS [U44 NS058229-02, U44NS058229-01, U44 NS058229-03S1, U44 NS058229-03, U44 NS058229-01, U44 NS058229] Funding Source: Medline
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Shiga toxin-producing Escherichia coli organisms (STEC) were detected by Gal-alpha 1,4-Gal glycopolydiacetylene (GPDA) nanoparticles through the selective binding between Shiga toxin and GPDA nanoparticles. The binding produced a colorimetric change in the absorption wavelength of the GPDA nanoparticles. This method provides a highly selective, rapid, sensitive, and quantitative approach for the detection of STEC. (c) 2007 Elsevier Ltd. All rights reserved.
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