Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 22, Issue 16, Pages 4395-4398Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.05.071
Keywords
Peptide Nucleic Acids; Oligonucleotide templated reaction; Biomarkers; Cell-free nucleic acids; Cancer
Funding
- Leverhulme Trust [RPG-2012-603]
- Cancer Research UK
- EU [CIG 293981]
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Sensing technologies based on Peptide Nucleic Acids (PNAs) and oligonucleotide-templated chemistry are perfectly suited for biomedical applications (e.g., diagnosis, prognosis and stratification of diseases) and could compete well with more traditional amplification technologies using expensive dual-labelled oligonucleotide probes. PNAs can be easily synthesised and functionalised, are more stable and are more responsive to point-mutations than their DNA counterpart. For these reasons, fluorogenic PNAs represent an interesting alternative to DNA-based molecular beacons for sensing applications in a cell-free environment, where cellular uptake is not required. (C) 2014 Elsevier Ltd. All rights reserved.
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