Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 22, Issue 14, Pages 3551-3564Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.05.008
Keywords
Fibrates; Nicotinic acid; Omega-3 fatty acids; PPAR alpha and PPAR alpha/gamma agonists; Squalene synthase inhibitors; Statins; Triglyceride-lowering agents
Ask authors/readers for more resources
This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPAR alpha and PPAR alpha/gamma agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered. Unfortunately, to date, harmless and effective triglyceride-lowering drug still does not exist and there is still need for development of better triglyceride-lowering agents. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available