Article
Biochemistry & Molecular Biology
Harrison J. Wensley, Wendy S. Smith, Suzanne E. Holmes, Sopsamorn U. Flavell, David J. Flavell
Summary: Triterpenoid saponins enhance the cytotoxicity of saporin-based immunotoxins by promoting the endolysosomal escape of the toxin to the cytosol. Various pharmacological inhibitors of different endocytic processes were used as probes to investigate the involvement of saponins in this process, with results suggesting a potential role of clathrin-mediated endocytosis and endosomal acidification in the internalization of saponins and the escape of toxins from the endolysosomal compartment to the cytosol. The correlation with the effects of these inhibitors on cytotoxicity augmentation provides additional evidence for the importance of endolysosomal escape in driving enhancement of cytotoxicity.
Article
Plant Sciences
Hayato Suzuki, Hikaru Seki, Toshiya Muranaka
Summary: The study reveals the subdivision and diversification of subclade IVa bHLHs in Fabaceae plants, with most of these transcription factors in Fabaceae belonging to group 1, which contains known saponin biosynthesis regulators. The findings will aid in the selection of unidentified saponin biosynthesis regulators. Additionally, the functions of groups 2 and 3 members are potential targets for studying the evolution of subclade IVa bHLH transcription factors in Fabaceae.
Article
Plant Sciences
Maria E. M. Marques, Ana C. de Carvalho, Anna C. A. Yendo, Yve V. S. Magedans, Eliane Zachert, Arthur G. Fett-Neto
Summary: Weeds pose major threats to agricultural and natural environments due to their ability to invade and compete. Bioherbicides, which are made of natural compounds that are biodegradable and have low residual effects, can be effective in controlling weeds. Certain plant species, like Quillaja lancifolia, produce compounds that have phytotoxic effects and can be explored as natural herbicides.
Review
Plant Sciences
Andrey S. Erst, Natalia V. Petrova, Olga A. Kaidash, Wei Wang, Vera A. Kostikova
Summary: This review summarizes the chemical composition and beneficial properties of Eranthis species. Seven out of around 14 species found in Asia and parts of Europe have been studied to various degrees. The results show that these plants contain various secondary metabolites and exhibit anti-inflammatory, antioxidant, antiviral, and other biological activities. The findings suggest the potential use of Eranthis species in drug development and biological synthesis.
Article
Biochemistry & Molecular Biology
Matheus da Silva Campelo, Cecilia Brilhante Araga, Izabell Maria Martins Teixeira, Erlania Alves de Siqueira, Carlos Jose Alves da Silva-Filho, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Cristiani Lopes Capistrano Goncalves de Oliveira, Celli Rodrigues Muniz, Francisco Geraldo Barbosa, Jair Mafezoli, Tiago Lima Sampaio, Maria Elenir Nobre Pinho Ribeiro
Summary: Pentacyclic triterpene-loaded emulsions were stabilized using polysaccharides from Agaricus blazei Murill mushroom (PAb). Compatibility tests showed no physicochemical incompatibilities between the drug and excipient. The addition of PAb at 0.75% resulted in stable emulsions with small droplet size, moderate polydispersity, and high zeta-potential. Encapsulation of the drug in PAb-stabilized emulsions improved its cytocompatibility against PC12 and murine astrocyte cells, reducing cytotoxicity and maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Thi Dieu Huong Hoang, Thi Kim Van Le, Thi Ha Do
Summary: Seven new triterpene glycosides were isolated from the extract of Elsholtzia penduliflora, and two of them showed significant cytotoxicity against human lung and breast cancer cells.
Article
Biochemistry & Molecular Biology
Xin-Fang Zhai, Ma-Li Zu, Yu-Rong Wang, Wei-Ye Cui, Yu Duan, Ce Yang, Xiang-Lan Piao
Summary: Gynostemma pentaphyllum has antioxidative potential, and the saponins from it are considered to be active compounds with safe and neuroprotective effects.
BIOORGANIC CHEMISTRY
(2021)
Review
Biodiversity Conservation
Rano Mamadalieva, Vahobjon Khujaev, Michal Soral, Nilufar Z. Mamadalieva, Michael Wink
Summary: The genus Allochrusa, native to Central Asia, Turkey, Iran, Afghanistan, and the Caucasus, has been widely used in folk medicine and in the preparation of sweets and detergents. It contains a variety of secondary metabolites, including triterpene glycosides, ecdysteroids, flavonoids, volatile compounds, fatty acids, polysaccharides, pectins, hemicelluloses, and other phytochemicals. Pharmacological studies have shown that compounds and extracts from Allochrusa species exhibit anti-inflammatory, adjuvant, hemolytic, cytotoxic, antifungal, analgesic, antioxidant, and other activities. This review summarizes the chemical compounds and diverse biological activities of the Allochrusa genus.
Article
Biochemistry & Molecular Biology
Nian Jiang, Changyan Yu, Jing Hui, Jianxun Xie, Yuanyuan Wang, Jun Yang, Sanhua Li, Lingjie Meng
Summary: A phytochemical investigation on the branches of Maytenus hookeri led to the discovery of fourteen compounds, including a new triterpene saponin, five phenylpropanoids, and eight lignans. The chemical structures of these compounds were determined through comprehensive spectroscopic data analysis and literature references. Furthermore, the chemotaxonomic significance of the isolated compounds was discussed in detail.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Plant Sciences
Bernhard Thalhamer, Markus Himmelsbach, Victoria Haider, Wolfgang Buchberger
Summary: Plant saponin extracts play a vital role in environmental rehabilitation and reducing gas emissions, but commercial products may be adulterated. This study developed a quantitative method to determine the main ingredient Misaponin A of Madhuca, revealing higher concentrations in Quillaja saponin extracts and contamination in other plant saponin extracts.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Shichao Ren, Qiuyan Sun, Liang Zhang, Wentao Sun, Yongxing Li, Xudong Feng, Chun Li
Summary: In this study, an artificial pathway for the de novo biosynthesis of Ro in Saccharomyces cerevisiae was successfully constructed through the selection of key enzymes and metabolic engineering strategies. The Ro titer was significantly increased, reaching a level more than 374,000-fold higher than reported data.
Article
Biochemistry & Molecular Biology
Beata Korchowiec, Jacek Korchowiec, Klaudia Kwiecinska, Reneta Gevrenova, Sabine Bouguet-Bonnet, Cheng Deng, Max Henry, Ewa Rogalska
Summary: The study investigated the interaction between GOTCAB saponin from the roots of Gypsophila paniculata L. and mammalian cell membrane models, revealing that cholesterol plays a crucial role in the interaction and location of the saponin within the lipid film.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Massimo Confalonieri, Maria Carelli, Silvia Gianoglio, Andrea Moglia, Elisa Biazzi, Aldo Tava
Summary: The study used CRISPR/Cas9 to knock out the genes responsible for synthesizing soyasapogenol B in Medicago species. Mutant plants did not produce soyasapogenol but instead diverted metabolic flux towards valuable hemolytic sapogenins. Mutants showed no adverse effects on plant morphology under greenhouse conditions and exhibited differential expression of saponin pathway genes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Applied
Shunqin Zeng, Xiangyuan Li, Zixuan Zhao, Yan Lin, Yindi Zhu, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meichun Wu, Haifeng Wu, Qiongyu Zou, Yongtao Li
Summary: Two new cycloartane triterpenoid glycosides and one known compound were isolated from the ethanolic extract of Actea vaginata rhizomes. Their structures were elucidated by spectroscopic methods and their cytotoxic activities against human cancer cell lines were tested.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Xiu-run Huang, Fang Cai, Jing Chen, Chang-hui Wu, Ye Li, Jian-hua Xu, Peng Li
Summary: A new lanostane-type triterpene, 3-oxo-5 alpha-lanosta-7,9(11)-dien-24-oic acid methyl ester (2), and three known compounds were isolated from the fruiting bodies of Ganoderma lucidum. The cytotoxic activity of these compounds against cancer cell lines was evaluated, and it was found that compound 1 exhibited strong cytotoxicity against SK-Hep-1, HepG2, and Hela cells, while compound 4 showed moderate cytotoxicity against Hela and Hela/VCR cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Food Science & Technology
Idris Arslan, Pinar Ili
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2015)
Article
Plant Sciences
Mamona Nazir, Henrik Harms, Irene Loef, Stefan Kehraus, Fayrouz El Maddah, Idris Arslan, Viktor Rempel, Christa E. Mueller, Gabriele M. Koenig
Article
Food Science & Technology
Idris Arslan
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2017)
Article
Plant Sciences
M. Celeste Varela, Idris Arslan, Mariana A. Reginato, Ana M. Cenzano, M. Virginia Luna
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2016)
Article
Plant Sciences
Peter Hufendiek, Simon Stephan Martin Stoelben, Stefan Kehraus, Nicole Merten, Henrik Harms, Max Cruesemann, Idris Arslan, Michael Guetschow, Tanja Schneider, Gabriele Maria Koenig
Article
Biochemistry & Molecular Biology
Idris Arslan
CHEMISTRY & BIODIVERSITY
(2014)
Article
Food Science & Technology
Ali Celik, Idris Arslan, Emine Nur Herken, Ahmet Ermis
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2013)
Article
Plant Sciences
Ana M. Cenzano, Idris Arslan
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Aylin Koseler, Idris Arslan, Ramazan Sabirli, Ali Zeytunluoglu, Oguz Kilic, Ismail Dogu Kilic
Summary: The study revealed an association between elevated plasma mannose levels and a higher risk of coronary artery disease in nondiabetic patients.
BIOMARKERS IN MEDICINE
(2021)
Article
Plant Sciences
Mariana Reginato, Ana M. Cenzano, Idris Arslan, Ana Furlan, Celeste Varela, Vanina Cavallin, Jutta Papenbrock, Virginia Luna
Summary: Different types of salt treatments lead to a differential modulation of the antioxidant systems, with polyphenols and other ROS-detoxifying compounds proposed to play a fundamental role in the cellular protection of P. strombulifera plants under severe oxidative stress, in conjunction with the enzymatic antioxidant system.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Biochemical Research Methods
Idris Arslan, Hafize Akgul, Murat Kara
Summary: Research suggests that Saporin, as a type I ribosome-inactivating protein, induces apoptosis through different pathways and shows potential therapeutic effects. Saporin-based targeted toxins may be promising therapeutic agents for treating SARS-CoV-2 infection.
Article
Chemistry, Medicinal
Idris Arslan, Ana M. Cenzano
Summary: Saponins are natural surfactant compounds that can form stable foam and micellar solutions in aqueous solutions. Gypsophila arrostii is the main source of saponins for industrial applications, such as vaccine adjuvants. Sophisticated techniques are required for the isolation and characterization of triterpene saponins, and electrospray ionization ion trap multiple-stage mass spectrometry has successfully characterized known Gypsophila-type saponins as well as detected previously undescribed saponin compounds.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)
Review
Chemistry, Medicinal
Idris Arslan
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2020)
Review
Chemistry, Medicinal
Idris Arslan, Ana M. Cenzano
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2020)
Article
Biotechnology & Applied Microbiology
Ali Celik, Ahmet Ermis, Emine N. Herken, Idris Arslan
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2013)