Editorial Material
Medicine, Research & Experimental
Keiichi Torimoto, Satoru Eguchi
Summary: The study highlights the role of sPRR as a ligand for AT1R, causing endothelial dysfunction and hypertension. The interaction between sPRR and AT1R contributes to obesity-induced cardiovascular diseases. The sPRR/AT1R complex may be a potential therapeutic target for endothelial dysfunction.
Article
Peripheral Vascular Disease
Lebo F. Gafane-Matemane, Ruan Kruger, Wayne Smith, Catharina M. C. Mels, Johannes M. Van Rooyen, Gontse G. Mokwatsi, Aletta S. Uys, Sanette J. Brits, Aletta E. Schutte
Summary: This study showed differences in the renin-angiotensin-aldosterone system, electrolytes, blood pressure, and total peripheral resistance between healthy young Black and White adults. RAAS concentrations were found to be half in Black adults compared to White adults, but the increase in blood pressure over time was faster in Black individuals. RAAS was similar in Black and White adults only in scenarios of low Na+/K+ values, indicating a potential essential role of potassium.
Article
Endocrinology & Metabolism
Fabio Bioletto, Chiara Lopez, Martina Bollati, Stefano Arata, Matteo Procopio, Federico Ponzetto, Guglielmo Beccuti, Giulio Mengozzi, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: This study investigated the feasibility of using aldosterone-to-renin ratio (ARR) as a diagnostic criteria for primary aldosteronism (PA) in patients with resistant hypertension (RH). The results showed that in normokalemic patients, ARR had a lower diagnostic accuracy and may not accurately differentiate between PA and essential RH. However, in patients with hypokalemia, ARR had a higher diagnostic accuracy and may serve as a diagnostic criterion for PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jun Yang, Stella May Gwini, Lawrence J. Beilin, Markus Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori
Summary: Oral contraception can increase the aldosterone to renin ratio, leading to false positive results in the screening for primary aldosteronism. Until more reliable criteria for primary aldosteronism screening in oral contraception users are established, alternative contraception methods should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Paolo Mulatero, Chiara Bertello, Franco Veglio, Silvia Monticone
Summary: Primary aldosteronism is an overlooked condition with significant mortality and morbidity. The difficulty of screening patients on antihypertensive therapy has resulted in low testing rates. However, interference with medication may not always be necessary for accurate screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Ryan J. McNally, Luca Faconti, Marina Cecelja, Bushra Farukh, Christopher N. Floyd, Philip J. Chowienczyk
Summary: This study investigated the effects of diuretic therapy on plasma renin activity (PRA) and found that diuretics lead to a sustained increase in PRA, with similar effects across different classes of diuretic, and that this increase is unrelated to the reduction in blood pressure.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Review
Physiology
Zachary Gray, Wanzhu Tu, Glenn M. Chertow, Vivek Bhalla
Summary: Aldosterone sensitivity is the response variable to a specific level of aldosterone, measured in differential tissue and blood pressure responses. This concept challenges traditional views of the renin-angiotensin-aldosterone system and may uncover novel mechanisms of hypertension, particularly in black individuals and older age groups.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chuanming Xu, Chunju Liu, Jianhua Xiong, Jun Yu
Summary: Cardiovascular diseases are major public health problems globally and the activation of the (Pro)renin receptor (PRR) plays a significant role in cardiovascular homeostasis. PRR activation is associated with myocardial ischemia/reperfusion injury, cardiac hypertrophy, heart failure, vascular smooth muscle cell proliferation, endothelial cell dysfunction, and the progression of vascular diseases. Targeting PRR may have benefits for patients with cardiovascular diseases.
Review
Peripheral Vascular Disease
John W. Funder, Robert M. Carey
Summary: Primary aldosteronism, the most common secondary form of hypertension, may have a higher prevalence than previously estimated. The screening rate for primary aldosteronism is currently low, and more research is needed to explore screening and treatment methods.
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Review
Cardiac & Cardiovascular Systems
Boyang Wang, Haipeng Jie, Shuangxi Wang, Bo Dong, Yunzeng Zou
Summary: (Pro)renin receptor (PRR) is a component of the renin-angiotensin system (RAS) and is involved in the pathogenesis of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on various cardiovascular conditions, including hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Antero Ylaenen, Ilkka Poersti, Riikka Nevalainen, Tero Hinkka, Heini Huhtala, Niina Matikainen, Esa Haemaelaeinen, Onni Niemelae, Pasi Nevalainen
Summary: This study investigated the association between renal cysts and non-suppressed plasma renin in patients with primary aldosteronism. It found that renal cysts are common in these patients and may interfere with diagnostics, especially in patients aged 50 years or less.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Naomi D. L. Fisher, Ajay J. Kirtane, Joost Daemen, Florian Rader, Melvin D. Lobo, Manish Saxena, Josephine Abraham, Roland E. Schmieder, Andrew S. P. Sharp, Philippe Gosse, Lisa Claude, Yang Song, Michel Azizi
Summary: This study investigated the association between plasma renin and aldosterone concentrations and the blood pressure response to renal denervation. The results showed that renal denervation reduced daytime ambulatory systolic blood pressure, but renin and aldosterone concentrations did not predict the blood pressure response to renal denervation.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Kazuomi Kario, Roland E. Schmieder, Konstantinos Tsiou, Stuart Pocock, Shukri David, Kiritkumar Patel, Anjani Rao, Antony Walton, Jason E. Bloom, Thomas Weber, Markus Suppan, Lucas Lauder, Sidney A. Cohen, Pamela McKenna, Martin Fahy, Michael Boehm, Michael A. Weber
Summary: The study aimed to evaluate the impact of renal denervation (RDN) on the renin-angiotensin-aldosterone system in blood pressure regulation. Results showed that plasma renin activity and aldosterone levels significantly decreased compared to baseline in RDN patients at 3 months, with higher baseline PRA levels associated with a more significant reduction in blood pressure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Chemistry, Medicinal
Jitendra A. Sattigeri, Malvika Garg, Pragya Bhateja, Ajay Soni, Abdul Rehman Abdul Rauf, Mahendrakumar Gupta, Mahesh S. Deshmukh, Tarun Jain, Nidhi Alekar, Tarani Kanta Barman, Paras Jha, Tridib Chaira, Ramesh B. Bambal, Dilip J. Upadhyay, Takahide Nishi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Biochemistry & Molecular Biology
Takashi Tsuji, Keisuke Suzuki, Tsuyoshi Nakamura, Taiji Goto, Yukiko Sekiguchi, Takuya Ikeda, Takeshi Fukuda, Toshiyasu Takemoto, Yumiko Mizuno, Takako Kimura, Yumi Kawase, Futoshi Nara, Takashi Kagari, Takaichi Shimozato, Chizuko Yahara, Shinichi Inaba, Tomohiro Honda, Takashi Izumi, Masakazu Tamura, Takahide Nishi
BIOORGANIC & MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Organic
Yutaka Mori, Mitsuhiro Iwamoto, Kazuki Mori, Masao Yoshida, Takeshi Honda, Takahiro Nagayama, Takahide Nishi
Article
Chemistry, Medicinal
Takashi Ohnuki, Masahiko Ejiri, Masaaki Kizuka, Mie Fujiwara, Takahide Nishi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Organic
Toshiki Yamashiro, Koji Yamada, Haruka Yoshida, Yutaro Tomisaka, Takahide Nishi, Takumi Abe
Article
Chemistry, Organic
Takahide Nishi, Naoki Mishima, Haruna Kato, Koji Yamada
Summary: A practical method for synthesizing heterocycle-2,3-fused indoline or azaindoline derivatives through haloetherification and cyclization was described and applied in syntheses of six- to eight-membered heterocycle-2,3-fused indoline and azaindoline derivatives, which contain sp(3)-hybridized carbons and might serve as new scaffolds in medicinal chemistry.
Article
Chemistry, Medicinal
Shingo Takiguchi, Hidehito Homma, Tetsunori Fujisawa, Yuki Hirota-Takahata, Yasunori Ono, Masaaki Kizuka, Yuki Ishii, Satomichi Yoshimura, Takahide Nishi
Summary: Novel cyclic peptide derivatives based on ogipeptins A, B, C, and D were synthesized using a practical four-step synthetic procedure to prepare compounds with various acyl side chains. Among 45 new synthetic derivatives identified, compounds 8-3 and 8-38 showed comparable antibacterial activities to ogipeptin A and significantly lower cytotoxicity (LD20 > 480 μM) in in vitro nephrotoxicity screening using LLC-PK1 cells compared to colistin (LD20 = 44.2 μM).
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Organic
Koji Yamada, Naoki Mishima, Kanae Saito, Takahide Nishi
Summary: This study presents a practical synthetic method for 3-bromo-2-hydroxy-1-tosylazaindolines and 2hydroxy-1-tosylazaindoline-3-triethylammonium bromides, which are stable crystals useful in the synthesis of biologically active 3-substituted 7-azaindole derivatives.
Article
Chemistry, Organic
Reina Kimura, Yoshihiro Sato, Kazuhiro Morisaki, Takahide Nishi
Summary: We investigated the [3 + 2] cycloaddition reactions of indoles and azaindoles with various nitrile oxides. N-protection with the 4-methoxybenzyl group proved to be effective for the [3 + 2] cycloaddition with nitrile oxides. Optimization of reaction conditions was necessary for unstable nitrile oxides due to their propensity to dimerize. This method was utilized for synthesizing key intermediates of biologically active 3-substituted azaindole derivatives.
Article
Chemistry, Organic
Shingo Takiguchi, Yuki Hirota-Takahata, Takahide Nishi
Summary: In this study, the Marfey's method was used to determine the configuration of β-OH Dab in ogipeptin A, confirming the 2:1 ratio of (2S,3S) to (2S,3R) β-OH Dab isomers in ogipeptins.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Shingo Takiguchi, Yuki Hirota-Takahata, Takahide Nishi
Summary: The absolute configuration of ogipeptins has been elucidated by the successful total synthesis of ogipeptin A.
Article
Chemistry, Organic
Ren Fukuya, Koji Yamada, Takahide Nishi
Summary: A practical method for synthesizing 7-azaserotonin and 7-azamelatonin was developed using a useful starting material, introducing new functional groups into the compounds.
Article
Chemistry, Organic
Koji Yamada, Kaho Ishizawa, Yoshihiro Oonishi, Yoshihiro Sato, Takahide Nishi
Summary: This study presents a practical synthetic method for accessing oxazolidinone-2,3-fused indoline and azaindoline derivatives through one-pot cyclization. These derivatives, which contain sp3-hybridized carbons, could serve as novel scaffolds in medicinal chemistry.
Article
Chemistry, Organic
Koji Yamada, Mariko Ohta, Go Kitamura, Suzuka Tsutsumiguchi, Takahide Nishi
Summary: A practical and facile method using specific starting materials was developed for synthesizing indole 3-acetic acid and azaindole 3-acetic acid derivatives. Key intermediates obtained from the reaction were used to introduce the acetic acid unit into the indole and azaindole skeletons. This method successfully synthesized 26 derivatives. (c) 2023 Elsevier Ltd. All rights reserved.
Review
Chemistry, Organic
Takumi Abe, Koji Yamada, Takahide Nishi
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
(2020)
