Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain

Plk1-targeted therapies in TP53- or RAS-mutated cancer

(2014) Hyungshin Yim et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

(2013) Hyungshin Yim   ANTI-CANCER DRUGS

Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes

(2013) Minhong Shen et al.   CELL RESEARCH

Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by a Mad2-Induced Functional Switch in Cdc20

(2013) Joo Seok Han et al.   MOLECULAR CELL

Polo-Like Kinases Inhibitors

(2012) L. Garuti et al.   CURRENT MEDICINAL CHEMISTRY

Polo Boxes Come out of the Crypt: A New View of PLK Function and Evolution

(2012) Swadhin Chandra Jana et al.   STRUCTURE

Bub1 and BubR1: at the Interface between Chromosome Attachment and the Spindle Checkpoint

(2011) S. Elowe   MOLECULAR AND CELLULAR BIOLOGY

DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1

(2010) Jing Zhang et al.   CANCER BIOLOGY & THERAPY

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells

(2010) Navdeep Chehl et al.   HPB

Polo-Like Kinase 1 Depletion Induces DNA Damage in Early S Prior to Caspase Activation

(2009) H. Yim et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

(2009) Sang-Moon Yun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovery of thiophene inhibitors of polo-like kinase

(2008) Kyle A. Emmitte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition

(2008) Nobumoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

(2008) Hongchang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint

(2008) M Lei et al.   ONCOGENE