Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 3, Pages 1256-1263Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.12.031
Keywords
Caffeoyl-anilide; Anti-HIV; Integrase inhibitor; CCR5 inhibitor; Portmanteau inhibitor
Funding
- Department of Biotechnology, Government of India [BT/PR7020/Med/14/930/2005]
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Designing multi-functional ligands is a recent strategy by which multiple targets can be inhibited by a single entity. A series of caffeoyl-anilide compounds based on structures of various integrase and CCR5 inhibitors have been designed and synthesized as anti-HIV agents in the present study. Most of the compounds exhibited potent anti-HIV activity at micromolar concentration in CEM-GFP CD4+ T cells infected with HIV-1NL4.3 virus. Compound 14 showed a lower EC50 and better TI as compared to AZT. Mechanism based studies suggest that these compounds inhibit either one or in some cases, both the targets. The experimental data and the docking results showed that these compounds are potential inhibitors for both HIV-1 IN and CCR5. (C) 2010 Elsevier Ltd. All rights reserved.
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