Article
Biochemistry & Molecular Biology
Lihong Cheng, Hiroyuki Osada, Tianyan Xing, Minoru Yoshida, Lan Xiang, Jianhua Qi
Summary: Amarogentin (AMA) induces neurite outgrowth in PC12 cells through targeting the insulin receptor and activating downstream signaling pathways, including Ras/Raf/ERK and PI3K/AKT. Additionally, AMA is found to be involved in multiple neurotrophic pathways, with phosphorylation reactions potentially playing a key role in its neuritogenic activity.
Article
Biochemistry & Molecular Biology
Yanan Liu, Qian Liu, Danni Chen, Akira Matsuura, Lan Xiang, Jianhua Qi
Summary: In this study, a compound called inokosterone was isolated from Gentiana rigescens Franch, a Chinese herb medicine, and its antiaging effects were investigated using yeast and mammalian cells. Inokosterone extended the lifespan of yeast and enhanced the survival ability of mammalian cells. The mechanism of action involved antioxidative stress and autophagy. The results indicate that inokosterone exerts its antiaging activity by reducing oxidative stress and increasing autophagy.
Article
Agricultural Engineering
Chunlu Liu, Tao Shen, Furong Xu, Yuanzhong Wang
Summary: In this study, a simple and rapid method for the correct identification of the geographical origins of Gentiana rigescens was developed. Marker components of iridoids were measured and used as a reference to characterize chemical profiles. The effects of climate factors on the content differences were examined. A novel two-dimensional correlation spectroscopy combined with deep learning was proposed for geographical origins identification. The results showed that this method provided a powerful tool for the cultivation and geographical origins identification of Gentiana rigescens.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Lan Xiang, Dejene Disasa, Yanan Liu, Rui Fujii, Mengya Yang, Enchan Wu, Akira Matsuura, Jianhua Qi
Summary: GTS B, a dammaren-type triterpenoid glycoside from the traditional Chinese medicinal plant G. rigescens Franch, has shown significant anti-aging effects by inhibiting the TORC1/Sch9/Rim15/Msn signaling pathway and enhancing autophagy in yeast. This compound also increases the enzymatic activities of key anti-oxidative enzymes and improves survival rate under oxidative stress conditions.
Article
Cell Biology
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri
Summary: This study investigates the different functions of ceramide in cellular differentiation and dedifferentiation. The results suggest that the function of ceramide heavily depends on its intracellular location, and further understanding of its function requires resolving its location during cellular status changes.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Nessma Sultan, Laila E. Amin, Ahmed R. Zaher, Mohammed E. Grawish, Ben A. Scheven
Summary: Dental pulp stem cells secrete neurotrophic factors that significantly promote cell survival and neurite outgrowth in PC12 cells, with NGF, BDNF, and GDNF playing important roles. These factors may have potential therapeutic applications for peripheral nerve repair.
NEURAL REGENERATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yu Liu, Lili Zou, Peng Wang, Jingxuan Zhou, Chunling Yuan, Jun Wang
Summary: The study investigated the role of nerve growth factor (NGF) in neurogenesis of breast cancer cells, revealing its potential importance in regulating cancer-associated neurogenesis and affecting the migration, invasion, and metastasis abilities of tumor cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Polymer Science
Qiuxia Li, Litao Sun, Xiaobei Huang, Shuai Liu, Haiyang Yong, Chenfei Wang, Jianzhong Li, Dezhong Zhou
Summary: Biodegradable and lipid-like highly branched poly(beta-amino ester)s (HPAESA) were developed to enhance the biological functions of adipose-derived stem cells by gene transfection. HPAESA showed significantly higher efficiency and cell viability, as well as the ability to promote neurite outgrowth.
Article
Biochemistry & Molecular Biology
Lihong Cheng, Yanhui Wang, Lan Xiang, Jianhua Qi
Summary: This study identified heat shock cognate 70 kDa protein (Hsc70) as the target protein of ABG-001 in PC12 cells, confirmed through inhibitors, cellular thermal shift assay (CETSA) and small-interfering RNA (siRNA) analysis. Inhibition of Hsc70 and siRNA significantly decreased ABG-001-induced neurite outgrowth, suggesting Hsc70 plays a key role in the neuritogenic activity of ABG-001.
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Horticulture
Xiaoli Bu, Huijuan Ji, Wenbao Ma, Changlong Mu, Ting Xian, Zhidong Zhou, Fei Wang, Jianhui Xue
Summary: Biochar, specifically rice husk biochar (RHB) and wood chip biochar (WCB), shows promise as a substitute for peat in horticultural plant production. In this study, the effects of RHB and WCB as components of a peat-based substrate on the growth and photosynthetic activity of Rhododendron delavayi seedlings were evaluated. Results showed that the addition of 20% WCB or 30-40% RHB enhanced the growth and photosynthetic activity of the seedlings, while the addition of 40% WCB had negative effects. The mixed substrates containing WCB or RHB had balanced porosity, suitable pH and electrical conductivity, and improved nutrient supply. This study suggests that a peat-based substrate with 20% WCB or 30-40% RHB is ideal for high-quality R. delavayi seedlings and sustainable horticulture production.
SCIENTIA HORTICULTURAE
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxu Wang, Yiyang Li, Yuliu Wang, Yanjun Liu, Changhu Xue, Peixu Cong, Jie Xu
Summary: By studying the neuritogenic activities and mechanisms of sea urchin gangliosides (SU-GLSs) in vitro, it was found that they promote differentiation of nerve cells and may act as neurotrophic factors for neuritogenesis.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Computer Science, Artificial Intelligence
Xiaolong Li, Wenwen Kong, Xiaoli Liu, Xi Zhang, Wei Wang, Rongqin Chen, Yongqi Sun, Fei Liu
Summary: This study applied LIBS and CNN technologies to quickly identify the geographical origin of Gentiana rigescens Franch. Two methods were proposed to address the issue of too many variables in LIBS spectra, leading to improved discrimination accuracy. The results demonstrated the potential application of this combined method in quickly identifying the geographical origin of traditional Chinese medicine.
FRONTIERS IN ARTIFICIAL INTELLIGENCE
(2021)
Article
Neurosciences
Yi-jun Liu, Xiao-feng Chen, Li-ping Zhou, Feng Rao, Dian-ying Zhang, Yan-hua Wang
Summary: This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect. Results showed that Wnt5a could promote Schwann cell proliferation and the expression of various neurotrophic factors, and the Wnt5a/Fn group outperformed the control groups in terms of nerve regeneration and functional recovery 12 weeks after the operation. The Wnt5a/Fn nerve conduit may promote peripheral nerve defect regeneration by facilitating multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Yong Xie, Xiaoyan Wang, Zhonghui Wang, Jianyang Feng, Dongsheng Li
Summary: This study aimed to investigate the effects of Fe3O4@ MSC-exo on PC12 cells and found that they can promote cell proliferation, migration, and neural differentiation.
Article
Chemistry, Medicinal
Lijuan Gao, Fengyang Chen, Xiaoyu Li, Shifang Xu, Wenhai Huang, Yiping Ye
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Plant Sciences
Jing Li, Lijuan Gao, Kaiyue Sun, Dan Xiao, Wanyi Li, Lan Xiang, Jianhua Qi
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Oncology
Xiao-Yu Li, Li-Fei Zhou, Li-Juan Gao, Yang Wei, Shi-Fang Xu, Feng-Yang Chen, Wen-Jing Huang, Wen-Fu Tan, Yi-Ping Ye
Article
Biochemistry & Molecular Biology
Lijuan Gao, Jinyou Li, Jianhua Qi
BIOORGANIC & MEDICINAL CHEMISTRY
(2010)
Article
Pharmacology & Pharmacy
Ruiqi Tang, Lijuan Gao, Makoto Kawatani, Jianzhong Chen, Xueli Cao, Hiroyuki Osada, Lan Xiang, Jianhua Qi
MOLECULAR PHARMACOLOGY
(2015)
