Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 230, Issue 12, Pages 2875-2880Publisher
WILEY
DOI: 10.1002/jcp.25036
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- Niedersachsen-Research Network on Neuroinfectiology (N-RENNT)
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A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post-mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non-canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons. (C) 2015 Wiley Periodicals, Inc.
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