Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 18, Issue 12, Pages 4530-4534Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.04.062
Keywords
Synthesis; Substituted phenalenones; Antiprotozoal activities
Funding
- Ministerio de Ciencia y Tecnologia [BQU2001-3721]
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A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiparasitic activities against the most clinically relevant forms of trypanosomiasis and leishmaniasis. Several compounds exhibited leishmanicidal effects at levels comparable or better than the reference drug pentamidine, while the parent phenalenone was shown to have a level of activity against Trypanosoma cruzi comparable to the marketed drug benznidazole. (C) 2010 Elsevier Ltd. All rights reserved.
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