Article
Agriculture, Dairy & Animal Science
Ronald J. J. Corbee, Jurriaan J. J. Mes, Govardus A. H. de Jong, Ronald T. M. van den Dool, Franka Neumer, Stephan Theis, Guido Bosch
Summary: The aim of this study was to compare the digestion and physiological effects of isomaltulose with other saccharides in dogs. The results showed that isomaltulose had a slower digestion and lower blood glucose response compared to sucrose. However, sucrose had a higher blood glucose response, suggesting the presence of an adaptive response. Therefore, further research on the digestion physiology of saccharides in dogs is warranted.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Eri Kokubo, Shunsuke Morita, Hirotaka Nagashima, Kazutaka Oshio, Hiroshi Iwamoto, Kazuhiro Miyaji
Summary: This study suggests that a low-carbohydrate oral dietary supplement can effectively reduce blood glucose levels in individuals with prediabetes. It contains slowly digestible carbohydrate, isomaltulose, and soluble dietary fiber, making it a suitable energy supplement for individuals with postprandial hyperglycemia.
Article
Nutrition & Dietetics
Ryota Kobayashi, Miki Sakazaki, Yukie Nagai, Kenji Asaki, Takeo Hashiguchi, Hideyuki Negoro
Summary: This study aimed to investigate the impact of different carbohydrates on arterial stiffness during hyperglycemia in middle-aged and older adults. Results showed that intake of isomaltulose effectively inhibited the acute increase in arterial stiffness, which may have significant clinical implications for dietary programs in middle-aged and elderly patients.
Article
Nutrition & Dietetics
Qingyuan Deng, Jillian J. Haszard, Tamlin S. Conner, Charlene Rapsey, Mei Peng, Bernard J. Venn
Summary: This study compared the effects of beverages with different glycemic responses (sucrose and isomaltulose) and a non-glycemic control (sucralose) on cognition, mood, and satiety. The results showed no convincing evidence that glycemic response had a significant effect on cognitive performance, mood, or satiety under the study conditions.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Masayuki Yamaguchi, Sayaka Iwamura, Kosuke Mine, Hiroshi Murakawa, Noriaki Hanasaki, Masaki Matsuda
Summary: A new electrically conducting molecular crystal with strong pi-d interaction was fabricated and studied for its negative magnetoresistance effect. It was found that enhancing the intermolecular antiferromagnetic interaction in molecular design is crucial for improving the negative magnetoresistance effect.
DALTON TRANSACTIONS
(2021)
Review
Food Science & Technology
Emilia Sokolowska, Anna Sadowska, Diana Sawicka, Izabela Kotulska-Bablinska, Halina Car
Summary: Studies have shown that isomaltulose, D-tagatose, and trehalose can positively impact blood glucose levels in diabetic patients, improve insulin response, and help control hyperglycemia.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Jose H. Correia, Jose A. Rodrigues, Sara Pimenta, Tao Dong, Zhaochu Yang
Summary: Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that selectively targets tumor cells by using photosensitizers and specific light wavelengths. New research on enhanced tumor selectivity of photosensitizers and improved effectiveness of PDT is being conducted, along with exploring new applications of PDT.
Review
Oncology
Wenqi Jiang, Mingkang Liang, Qifang Lei, Guangzhi Li, Song Wu
Summary: Photodynamic therapy (PDT) is a non-invasive cancer treatment strategy with broad clinical applications. This review summarizes the advances of novel photosensitizers (PSs) characterized by high conversion efficiency and additional features. It also demonstrates the development of PDT-based combination therapies with excellent neoplastic ablation efficiency.
Article
Anatomy & Morphology
Xiaojin Liu, Hao Lv, Haibin Shen
Summary: This study investigates the combined effects of Vitamin D, ALA-PDT, and paclitaxel on breast cancer. The results show that Vitamin D enhances the therapeutic effects of this treatment regimen on tumor growth and cell apoptosis.
Article
Biotechnology & Applied Microbiology
Yannan Wu, Jiahui Sun, Xuejing Xu, Shaoming Mao, Guodong Luan, Xuefeng Lu
Summary: This study successfully introduced different sucrose isomerases into a fermentation bacterium, and achieved the synthesis and accumulation of isomaltulose in the recombinant strains, leading to increased production. This work provided a new pathway for isomaltulose biosynthesis utilizing carbon dioxide as the substrate, and offered novel insights into the plasticity of cyanobacterial photosynthetic metabolism network.
JOURNAL OF BIOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Anna Kordowski, Axel Kuenstner, Lisa Schweitzer, Stephan Theis, Torsten Schroeder, Hauke Busch, Christian Sina, Martin Smollich
Summary: This study examines the impact of incorporating isomaltulose and ITF into the habitual diet on glycemic control and gut microbiota. Results show that isomaltulose-sweetened drinks lead to lower postprandial glycemia compared to sucrose-sweetened drinks. Furthermore, ITF supplementation improves glucose control and positively modulates gut microbiota. The study suggests interindividual differences in glycemic response to ingredients and a possible relationship between gut microbiota and glycemic response.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Nikita Suvorov, Viktor Pogorilyy, Ekaterina Diachkova, Yuri Vasil'ev, Andrey Mironov, Mikhail Grin
Summary: The rapid growth of drug-resistant bacteria has led to a major research challenge in finding alternative treatments, such as photodynamic therapy using photosensitizers and visible light at a certain wavelength to treat bacteria. Chlorophyll derivatives play a special role in this antimicrobial PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Wei Su, Xiantao Jiang, Ying Zhang, Chenxiang Lin, Jun 'An Xiao, Peiyuan Li
Summary: In this study, a novel strategy was developed for fabricating self-assembled naphthalocyanine photosensitizers (SiNc@CEL) with unique photochemical and photophysical properties. SiNc@CEL could be disassembled under the photothermal effect and its photoactivity could be enhanced by 780 nm laser irradiation. SiNc@CEL generated reactive oxygen species and had good photothermal properties, facilitating the application of multi-functional phototherapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Electrochemistry
Giulia Moggia, Jonathan Schalck, Nick Daems, Tom Breugelmans
Summary: The study conducted glucose electrooxidation to glucaric acid for the first time in a batch reactor using a bare gold electrode. The optimal conditions yielded a maximum selectivity of 97.6% for gluconic acid and 89.5% for glucaric acid, the highest reported values to date.
ELECTROCHIMICA ACTA
(2021)
Article
Nutrition & Dietetics
Hannah L. Notbohm, Joshua F. Feuerbacher, Finn Papendorf, Nils Friese, Mats W. Jacobs, Hans-Georg Predel, Jonas Zacher, Wilhelm Bloch, Moritz Schumann
Summary: Isomaltulose ingestion led to lower baseline postprandial concentrations of glucose, insulin, and GIP compared to maltodextrin and glucose, and reduced blood glucose fluctuations during treadmill running. However, no differences were observed in fat and carbohydrate oxidation rates, running performance, and gastrointestinal discomfort between the conditions.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2021)
Review
Chemistry, Multidisciplinary
Xiaoyang Yue, Yves Queneau
Summary: This Review discusses the use of HMF, furfural, and furan as platforms for designing alternative surfactants, highlighting the various methods for grafting polar and non-polar appendages and exploiting their specific chemical reactivity. The surfactants sector will benefit from these alternatives, enabling increased renewable carbon content and structural innovation.
Article
Biochemistry & Molecular Biology
Thibaut Barbier, Alexia Barbry, Jeremy Magand, Cedric Badiou, Floriane Davy, Anne Baudouin, Yves Queneau, Oana Dumitrescu, Gerard Lina, Laurent Soulere
Summary: In this study, new series of compounds were synthesized by combining the benzo[b]thiophene nucleus and the acylhydrazone functional group for screening against Staphylococcus aureus. Among the compounds tested, (E)-6-chloro-N'-(pyridin-2-ylmethylene)benzo[b]thiophene-2-carbohydrazide (II.b) showed promising antimicrobial activity with a minimal inhibitory concentration of 4 μg/mL against S. aureus strains, including clinically isolated strains resistant to methicillin and daptomycin.
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas, Vincent Chaleix, Vincent Sol
Summary: In this study, cationic porphyrin-xylan conjugate hydrogels were successfully synthesized and showed good mechanical properties and antibacterial activity against common bacterial strains under light irradiation.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Medicinal
Charly Gourlot, Alexis Gosset, Elise Glattard, Christopher Aisenbrey, Sabarinathan Rangasamy, Morgane Rabineau, Tan-Sothea Ouk, Vincent Sol, Philippe Lavalle, Christophe Gourlaouen, Barbara Ventura, Burkhard Bechinger, Valerie Heitz
Summary: The increase of antimicrobial resistance is a major health problem worldwide, and new bactericidal strategies are needed. Antimicrobial photodynamic therapy (a-PDT) can generate reactive oxygen species to target cellular structures, reducing the risk of bacterial resistance. A new conjugate consisting of an antimicrobial peptide and a pi-extended porphyrin photosensitizer has been designed to effectively kill both Gram-positive and Gram-negative bacteria when excited by near IR. Moreover, this conjugate can achieve a low minimum bactericidal concentration without causing toxicity to skin cells.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Romain Villeger, Emilie Pinault, Karine Vuillier-Devillers, Karine Grenier, Cornelia Landolt, David Ropartz, Vincent Sol, Maria C. Urdaci, Philippe Bressollier, Tan-Sothea Ouk
Summary: This study found that using isomaltooligosaccharides (IMOSs) can improve the fitness and benefits of probiotic Bacillus subtilis CU1. IMOSs can modify the metabolism and functions of the strain, enhance the germination of Bacillus subtilis CU1, and increase the concentration of the strain.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Frederique Bregier, Vincent Sol, Yves Champavier, Laurent Galmiche, Clemence Allain, Pierre Audebert
Summary: The study presents the synthesis of a porphyrin linked to a heptazine photoactive antenna, demonstrating the activity of both components. While they exhibit independent electrochemical behavior, spectroscopy reveals energy transfer between the two partners.
Article
Biochemistry & Molecular Biology
Thibaut Barbier, Cedric Badiou, Floriane Davy, Yves Queneau, Oana Dumitrescu, Gerard Lina, Laurent Soulere
Summary: In this study, five series of heterocyclic tripartite 2,6-difluorobenzamides were synthesized to investigate the influence of the nature of the heterocyclic central scaffold on the biological activity against Staphylococcus aureus. Among the compounds, II.c showed low minimum inhibitory concentration and exhibited no cytotoxicity against human cells.
Article
Chemistry, Organic
Jingjing Jiang, Yves Queneau, Florence Popowycz
Summary: The use of the renewable platform molecule 5-HMF in multi-component reaction with a diamine and an alkynone to generate seven-membered 1,5-benzodiazepines is described. Ammonium acetate in ethanol proved to be a clean and efficient system among catalysts/solvents couples. The optimized conditions were used to investigate the scope of the reaction providing a library of 1,5-benzodiazepines in moderate to good yields from a wide range of diversely substituted diamines and alkynones or alkyl alkynoates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Thibaut Barbier, Oana Dumitrescu, Gerard Lina, Yves Queneau, Laurent Soulere
Summary: A conformational analysis and molecular docking study compared 2,6-difluoro-3-methoxybenzamide (DFMBA) with 3-methoxybenzamide (3-MBA) to investigate the effect of fluorination on FtsZ inhibition and anti S. aureus activity. The presence of fluorine atoms in DFMBA resulted in a non-planar conformation, making it more adaptable to the reported co-crystallized complexes with FtsZ. Molecular docking studies showed strong hydrophobic interactions between the difluoroaromatic ring and residues Val203, Val297, and Asn263, as well as critical hydrogen bonds with residues Val207, Leu209, and Asn263. Changing the carboxamide functional group to benzohydroxamic acid or benzohydrazide rendered the compounds inactive, emphasizing the importance of the carboxamide group.
Review
Biochemistry & Molecular Biology
Qiang Zhang, Laurent Soulere, Yves Queneau
Summary: Compounds with thioamide function are important in organic synthesis as key building blocks and in drug design due to their ability to mimic amide function in biomolecules. This review provides an update on the last decade's contributions in the formation of thioamides using different sulfur sources, highlighting the cleanliness and practicality of the new methods.
Review
Pharmacology & Pharmacy
Hicham Wahnou, Ibtissam Youlyouz-Marfak, Bertrand Liagre, Vincent Sol, Mounia Oudghiri, Raphael Emmanuel Duval, Youness Limami
Summary: Prostate cancer is a major concern worldwide, and current treatments have limitations and side effects. Photodynamic therapy (PDT) is a promising alternative that uses light-activated photosensitizers to induce tumor cell death. There are synthetic and natural photosensitizers, and combining PDT with other therapies is being explored. This review provides an overview of conventional treatments, principles of PDT, different types of photosensitizers, and ongoing research on combination therapy for prostate cancer. PDT has the potential to be a more effective and less invasive treatment option, and research aims to improve its selectivity and efficacy.
Article
Biochemistry & Molecular Biology
Laurent Soulere, Thibaut Barbier, Yves Queneau
Summary: Comparative analysis of amino acid sequences and 3D structural alignment revealed significant structural homologies between the main proteases of SARS-CoV-2 and IBV. In silico screening using a PubChem BioAssay database identified four covalent inhibitors and five non-covalent inhibitors for SARS-CoV-2 protease. Molecular dynamics simulations further investigated the binding of these inhibitors, and predictive ADMET calculations suggested promising pharmacokinetic properties for the nine compounds.
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Article
Chemistry, Multidisciplinary
Fahima Ali-Rachedi, Stephen J. J. Cowling, Stephane Chambert, Yves Queneau
Summary: Glycosteroids, including synthetic monocatenar carbohydrate steroid hybrids, have been synthesized by connecting carboxymethylglycosyl lactone-based allyl amides with allylated steroids through cross-metathesis reaction. The reaction successfully utilized glucose, galactose, cellobiose, and dihydrocholesterol as substrates, resulting in the synthesis of variously protected new glycosteroids.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Review
Oncology
Salma Benayad, Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre, Vincent Sol, Mounia Oudghiri, El Madani Saad, Raphael Emmanuel Duval, Youness Limami
Summary: With its potential to inhibit cancer development, piperine, a natural compound, shows promise in cancer prevention and treatment.
