Article
Biochemistry & Molecular Biology
Salvatore Antonucci, Moises Di Sante, Federica Tonolo, Laura Pontarollo, Valeria Scalcon, Petra Alanova, Roberta Menabo, Andrea Carpi, Alberto Bindoli, Maria Pia Rigobello, Marco Giorgio, Nina Kaludercic, Fabio Di Lisa
Summary: The study demonstrates the crucial role of monoamine oxidases (MAOs) in oxidative stress and mitochondrial dysfunction in doxorubicin cardiomyopathy. Pharmacological inhibition of MAOs can alleviate the dysfunctions leading to cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cell Biology
Artyom Y. Baev, Andrey Y. Vinokurov, Irina N. Novikova, Viktor V. Dremin, Elena V. Potapova, Andrey Y. Abramov
Summary: Neurodegenerative disorders are devastating diseases characterized by the loss of neurons in specific brain regions. Recent research has identified genes, toxins, and risk factors associated with these diseases, and has found similarities in the involvement of mitochondria, oxidative stress, and abnormal calcium signaling in neurons and astrocytes.
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Katarina Zlatic, Matija Popovic, Lidija Uzelac, Marijeta Kralj, Nikola Basaric
Summary: A series of BODIPY compounds with different substituents were synthesized, and their spectral, photo-physical properties, and photochemical reactivity in CH3OH were investigated. The substitution at the meso-position and phenolic moiety influenced the reaction selectivity and efficiency. The introduction of halogen atoms enhanced the photo-cleavage reaction efficiency and the ability to sensitize oxygen and form reactive oxygen species (ROS).
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Xiaoting Sun, Yuanyuan Li, Yanqi Lin, Yuanyuan Mei, Lingli Lin, Kuo-Ting Ho, Jialin Zhan, Chaoxiang Chen, Jun Zeng, Jian Li, Jingwen Liu, Guiling Li
Summary: This study found that curcumin can enhance cellular antioxidant capacity and mitochondrial function by downregulating miR-22-3p and targeting CRLS1 gene.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Andrey Y. Vinokurov, Olga A. Stelmashuk, Polina A. Ukolova, Evgeny A. Zherebtsov, Andrey Y. Abramov
Summary: The brain produces various reactive oxygen species at different rates in different brain regions, with the brain stem and cerebellum being more sensitive to oxidative stress. Mitochondrial ROS has minor implications to total ROS production, and levels of lipid peroxidation and GSH vary across brain regions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Andre J. van der Vlies, Masoud Ghasemi, Bernadette M. Adair, James H. Adair, Enrique D. Gomez, Urara Hasegawa
Summary: Hydrogen sulfide (H2S) is a gaseous signaling molecule with regulatory roles in cancer cell proliferation and migration, making it of interest in cancer therapy. Controlled delivery of H2S has been a challenge, but polymeric micelles containing H2S donating groups offer a solution. These micelles release H2S upon oxidation by reactive oxygen species (ROS) present inside cancer cells, with the release profiles controlled by changing the polymer design. In vitro and in vivo experiments demonstrate that micelles with moderate H2S release rates have the strongest anti-proliferative effect in human colon cancer cells and the chick chorioallantoic membrane cancer model, while not affecting human umbilical vein endothelial cell proliferation. This study highlights the importance of fine-tuning H2S release profiles using a micelle approach for maximizing the therapeutic potential of H2S in cancer treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Hulya Gizem Oezkan, Andriy Mokhir
Summary: Hybrid drugs containing ferrocene and phenol residues exhibit potent anticancer activity, but their mode of action, specificity, and metabolism need further investigation. In this study, we synthesized prodrugs of aminoferrocene-phenol hybrids and confirmed their activation in cancer cells while remaining inactive in normal cells. The anticancer activity of the prodrug relies on the generation of reactive oxygen species in cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ivan Menendez-Montes, Salim Abdisalaam, Feng Xiao, Nicholas T. Lam, Shibani Mukherjee, Luke I. Szweda, Aroumougame Asaithamby, Hesham A. Sadek
Summary: Mitochondrial utilization of fatty acids induces a significant increase in ROS detection at the chromatin level, indicating that mitochondrial metabolic perturbations directly alter the nuclear redox status, with chromatin being particularly sensitive to the prooxidant effect of FA utilization by the mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Mariafrancesca Hyeraci, Laura Agnarelli, Luca Labella, Fabio Marchetti, Maria Luisa Di Paolo, Simona Samaritani, Lisa Dalla Via
Summary: Resistance to cisplatin limits its usefulness as an anticancer drug. This study describes the synthesis and characterization of two new platinum complexes and demonstrates their potential in overcoming cisplatin resistance in cancer cells. The complexes exhibited poor ability to platinate DNA but showed significant intracellular accumulation. Mechanistic studies revealed their ability to inhibit DNA relaxation and activate the apoptotic pathway. Comparison with related complexes provides insights into the resistance phenotype.
Review
Biochemistry & Molecular Biology
Valeria Poggetti, Silvia Salerno, Emma Baglini, Elisabetta Barresi, Federico Da Settimo, Sabrina Taliani
Summary: Carbonic anhydrases (CAs) are important enzymes involved in pH regulation and body fluid balance. Activators of CAs have been identified and may have potential therapeutic applications for neurodegenerative diseases.
Article
Chemistry, Medicinal
Marco Robello, Silvia Salerno, Elisabetta Barresi, Paola Orlandi, Francesca Vaglini, Marta Banchi, Francesca Simorini, Emma Baglini, Valeria Poggetti, Sabrina Taliani, Federico Da Settimo, Guido Bocci
Summary: Novel 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazine (BIT) derivatives were designed and synthesized, showing antiproliferative activity against human colorectal adenocarcinoma cells and human dermal microvascular endothelial cells. The most active compounds, 2-4 and 8, target the microtubule cytoskeleton and induce dense microtubule accumulation at the periphery of cancer cells.
ARCHIV DER PHARMAZIE
(2022)
Article
Integrative & Complementary Medicine
Massimo Bonucci, Andrea Geraci, Dina Pero, Cristina Villiva, Daniele Cordella, Maria Condello, Stefania Meschini, Laura Del Campo, Franco Tomassi, Alessandro Porcu, Francesco De Lorenzo, Francesco Lozupone
Summary: The use of traditional, complementary, integrative, and alternative medicine (TCIM) is common among cancer patients, with natural products and mind-body practices being the most commonly used. The main reasons for using TCIM are to alleviate treatment side effects and improve the patients' physical and mental well-being. However, patients often use natural products without consulting a doctor, leading to inappropriate use.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Oncology
Maria Condello, Gloria D'Avack, Enrico Pierluigi Spugnini, Stefania Meschini
Summary: Electrochemotherapy is an innovative strategy to tackle multidrug resistance in cancer, enhancing the uptake of chemotherapeutic agents into tumors and potentially improving treatment outcomes.
Article
Biochemistry & Molecular Biology
Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Valeria Mazzi, Armando Patrizio, Simona Piaggi, Enke Baldini, Marco Centanni, Concettina La Motta, Alessandro Antonelli, Poupak Fallahi
Summary: This study evaluated the antineoplastic effect of multitarget tyrosine kinase inhibitor pazopanib in primary human anaplastic thyroid cancer cells in vitro. The results showed that pazopanib inhibited cell proliferation, migration, and invasion, and increased apoptosis. Moreover, pazopanib significantly decreased the expression of VEGF in the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eleonora Colombo, Davide Andrea Coppini, Laura Polito, Umberto Ciriello, Giuseppe Paladino, Mariafrancesca Hyeraci, Maria Luisa Di Paolo, Giulia Nordio, Lisa Dalla Via, Daniele Passarella
Summary: Cannabidiol (CBD), a compound found in Cannabis plants, is shown to be an effective inducer in the formation of nanoparticles. These nanoparticles, formed through solvent displacement, exhibit monodisperse and stable structures. They show low micromolar range cytotoxicity on human tumor cell lines, with the involvement of paclitaxel confirmed in the most effective nanoparticle (NP 8B) through further biological assays.
Review
Biochemistry & Molecular Biology
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Sabrina Taliani, Federico Da Settimo
Summary: G-quadruplex (G4)-targeting compounds and Topo inhibitors are promising strategies to target tumor cells.
Simultaneous stabilization of G4 and inhibition of Topos can enhance antiproliferative activity and overcome cellular insensitivity and resistance.
Some chemotypes with dual activity and interesting pharmacological profile have been identified, but research in this field is still limited.
Article
Biochemistry & Molecular Biology
Sara Boumya, Silvia Fallarini, Sonia Siragusa, Giovanni Petrarolo, Silvio Aprile, Valentina Audrito, Concettina La Motta, Silvia Garavaglia, Laura Moro, Giulia Pinton
Summary: Aldehyde dehydrogenase 1A3 (ALDH1A3) has been linked to poor prognosis in malignant pleural mesothelioma (MPM). Inhibition of ALDH1A3 using NR6 resulted in the accumulation of toxic aldehydes, DNA damage, CDKN2A expression, and cell growth arrest. NR6 treatment also affected the tumor microenvironment by altering IL6, CXCL8, and IL-8 levels, and shifting cell fate from senescence to apoptosis. Understanding the role of ALDH1A3 in MPM cells and the tumor microenvironment could lead to potential new treatments for this cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Federico Da Settimo, Sabrina Taliani
Summary: Glioblastoma (GBM) is a highly aggressive and common primary brain tumor with a poor prognosis and high mortality rate. Current treatment options, including surgical resection, radiotherapy, and chemotherapy, have limited efficacy. This review focuses on the therapeutic benefits and clinical development of novel indole-based derivatives as potential anti-GBM agents. It discusses the current pre-clinical and clinical stage compounds, emphasizing the recent advances between 2013 and 2022. The mechanisms of action, such as protein kinase, tubulin, and p53 pathway inhibition, are also analyzed.
Article
Biochemistry & Molecular Biology
Giulia Nordio, Francesco Piazzola, Giorgio Cozza, Monica Rossetto, Manuela Cervelli, Anna Minarini, Filippo Basagni, Elisa Tassinari, Lisa Dalla Via, Andrea Milelli, Maria Luisa Di Paolo
Summary: Monoamine oxidases (MAOs) have been widely studied in neurological diseases, but recent research has discovered their potential role in certain types of cancer. This study identified novel MAO inhibitors with antiproliferative activity, suggesting their potential as anticancer agents.
Article
Pharmacology & Pharmacy
Lidia Ciccone, Caterina Camodeca, Nicolo Tonali, Lucia Barlettani, Armando Rossello, Carole Fruchart Gaillard, Julia Kaffy, Giovanni Petrarolo, Concettina La Motta, Susanna Nencetti, Elisabetta Orlandini
Summary: A series of new hybrid derivatives inspired by nature were synthesized and studied as multifunctional agents for the treatment of Alzheimer's disease. These compounds combine bioactive moieties with the ability to chelate biometals and exhibit antioxidant activity.
Review
Chemistry, Medicinal
Elisabetta Barresi, Marco Robello, Emma Baglini, Valeria Poggetti, Monica Viviano, Silvia Salerno, Federico Da Settimo, Sabrina Taliani
Summary: In recent years, indolylglyoxylamide-based derivatives have been extensively studied for their potential in drug design and discovery, resulting in a wide range of compounds with diverse pharmacological activities. This review focuses on the elegant utilization of the indolylglyoxylamide moiety by medicinal chemists to develop potential drugs, particularly those showing in vivo activity or undergoing clinical trials. The information provided in this review offers valuable insights and perspectives for further research and design of indolylglyoxylamide-based molecules with promising pharmacological profiles.
Article
Chemistry, Inorganic & Nuclear
Anna Farasat, Luca Labella, Maria Luisa Di Paolo, Lisa Dalla Via, Simona Samaritani
Summary: This study synthesized a series of new N-acyclic carbene and isonitrile complexes of platinum(II). Among them, NAC derivatives showed a moderate cytotoxic effect on MSTO-211H cells.
Article
Pharmacology & Pharmacy
Osmar Antonio Jaramillo-Morales, Erik Diaz-Cervantes, Lisa Dalla Via, Aida Nelly Garcia-Argaez, Josue Vidal Espinosa-Juarez, Jose Carlos Ovando-Zambrano, Victor Manuel Munoz-Perez, Carmen Valadez-Vega, Mirandeli Bautista
Summary: The study aimed to evaluate the hepatoprotective effect of verbascoside on liver damage induced by thioacetamide and demonstrated that verbascoside can interact with a cancerous target, reducing liver injury.
SCIENTIA PHARMACEUTICA
(2023)