Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 9, Pages 5085-5089Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.03.030
Keywords
1-aminoanthracene; biotransformaion; Beauveria bassiana; microbial metabolism; acetylation; oxidation; hydroxylation; O-methylglucosylation
Funding
- NCI NIH HHS [R01 CA 90265] Funding Source: Medline
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The carcinogen and mutagen, 1-aminoanthracene, was efficiently metabolized by the fungal strain Beauveria bassiana ATCC 7159 to yield three new metabolites identified as 1-acetamido-5-[(4'-O-methyl-beta-D-glucopyranosyl)oxy]anthracene, 1-acetamido8-[(4'-O-methyl-beta-D-glucopyranosyl)oxy]anthraquinone, and 1-acetamido-6-[(4'-O-methyl-beta-D-glucopyranosyl) oxy] anthraquinone, together with 1-acetamidoanthracene and 1-acetamidoanthraquinone. Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation. (c) 2008 Published by Elsevier Ltd.
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