Article
Chemistry, Multidisciplinary
Woo Jin Lee, Wan Yi Li, Sang Woo Lee, Sung Keun Jung
Summary: The extract of Soroseris hirsuta demonstrates anti-inflammatory and antioxidant effects on LPS-activated murine macrophages, inhibiting nitric oxide expression and key signaling pathways related to inflammation and oxidative stress.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Inorganic & Nuclear
Ana C. Pena, Ana Pamplona
Summary: Transition metals, especially iron, play important roles in the chemistry of life. Hemoproteins, including hemoglobin, are common targets for binding with biologically active gases such as NO and CO. Heme oxygenases, particularly HO-1, are crucial enzymes involved in heme metabolism and have documented antioxidant and anti-inflammatory properties. However, their role in infection, such as malaria, can be dual, either limiting pathogen burden or promoting pathogen growth. CO-releasing molecules have been considered as a potential alternative to CO gas inhalation for therapeutic purposes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Joseana de Oliveira, Marina B. Denadai, Diego L. Costa
Summary: Heme oxygenase-1 (HO-1) plays a crucial role in iron metabolism and has the potential to modulate immunity and inflammation through regulating cellular oxidation reactions and the expression of inflammation-related proteins.
Article
Plant Sciences
Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui
Summary: This study reveals that hemin treatment increases anthocyanin accumulation in radish sprouts through HO-1 and NO signaling network.
Article
Chemistry, Multidisciplinary
Xiaodi Rong, Yiyuan Peng, Caiyun Liu, Mingzhu Li, Jiafan Shi, Miaohui Yu, Shuaikang Ba, Wenlong Sheng, Baocun Zhu
Summary: In this study, the issues of sensitivity, selectivity, and water solubility of CO fluorescent probes were investigated. A probe named HS-CO was designed to greatly increase the rigid plane of the probe through intramolecular cyclization, resulting in high sensitivity for CO detection. The probe was successfully used to detect CO in HeLa cells and zebrafish, demonstrating its great potential as a tool for functional analysis of CO in organisms.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis
Summary: This study suggests that G protein-coupled estrogen receptor 1 (GPER1) does not play a significant role in cisplatin-induced acute kidney injury (AKI), but its deletion exacerbates renal apoptosis and diminishes heme oxygenase-1 (HO-1) induction, indicating potentially important cytoprotective and anti-apoptotic actions of GPER1 in AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shaolin Tan, Yuangang Su, Linke Huang, Siyu Deng, Guohua Yan, Xue Yang, Runfeng Chen, Yansi Xian, Jiamin Liang, Qian Liu, Jianwen Cheng
Summary: Cor can inhibit osteoclastogenesis and bone resorption, reduce inflammator- induced bone defects, making it a potential therapeutic agent for osteoclast-mediated osteolytic diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Chemistry, Applied
Na Yeon Kim, Sooji Kim, Hwa Jin Lee, Jae-Ha Ryu
Summary: Four sesquiterpenoids were isolated from A. princeps ethanolic extract, and they showed anti-inflammatory activity by up-regulating the Nrf2/HO-1 pathway.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Article
Immunology
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Gi-Sang Bae, Sung-Joo Park
Summary: Guggulsterone (GS) exerts anti-inflammatory effects by inducing heme oxygenase-1 (HO-1) expression through reactive oxygen species (ROS) production. GS inhibits the expression of inflammatory mediators and prolongs survival in an endotoxemia model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Plant Sciences
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Summary: Although the use of molecular hydrogen (H-2) for enhanced plant growth and postharvest storage of crops has not been widely accepted in the UK, evidence shows that it can alleviate plant stress and slow crop senescence. The effects of H-2 treatment appear to be mediated by the alteration of plant cell antioxidant capacity, with potential benefits in agriculture if the costs are justified. Hydrogen-rich water (HRW) is considered safe and relatively easy to use, suggesting that it could potentially be widely adopted in the UK and help reduce food waste in the future.
Article
Immunology
Zhizhongbin Wu, Yilin Huang, Weiqing Hu, Liyin Ren, Peihua Jiang, Robert F. Margolskee, Hong Wang, Shan Feng
Summary: This study found that a subset of taste bud cells and taste neurons express iNOS proteins after inflammation stimulation, and isolated mouse taste epithelium can release NO in vitro. Furthermore, NO may play an important role in inflammation-associated taste disturbances.
BRAIN BEHAVIOR AND IMMUNITY
(2022)