Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
F. Pamuk, M. Lutfioglu, T. Paksoy, C. Z. Koyuncuoglu, N. G. Polat, E. Cifcibasi, S. Yildirim, A. Kantarci
Summary: The study found that low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment can modulate the plasminogen-activating system in severe periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Hematology
Tae Ito, Yuko Suzuki, Hideto Sano, Naoki Honkura, Francis J. Castellino, Tetsumei Urano
Summary: The study demonstrates the existence of three distinct forms of high-molecular-weight complexes between tPA and PAI-1. Peptide sequence analysis revealed that these complexes consist of nonacylated-enzyme inhibitor complexes, with only a fraction of the population releasing free tPA under physiological conditions.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Max Liu, Khalequz Zaman, Yolanda M. Fortenberry
Summary: Aptamers are single-stranded DNA or RNA sequences that exhibit high specificity and affinity in binding target molecules. They are non-immunogenic, easier to synthesize and modify, and can bind targets with greater affinity, making them a promising therapeutic candidate for treating various conditions. Active research is ongoing in developing aptamers to target blood coagulation factors, with potential applications in treating cardiovascular diseases, blood disorders, and cancers. Although no aptamers targeting blood coagulation factors have been approved for clinical use, several have shown promise in clinical trials and preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kiyotaka Okada, Naoyuki Kawao, Daisho Nakai, Rei Wakabayashi, Yoshitaka Horiuchi, Katsumi Okumoto, Shinji Kurashimo, Yoshimasa Takafuji, Osamu Matsuo, Hiroshi Kaji
Summary: This study demonstrated that glucocorticoids decrease the number of macrophages at the injured site during early bone repair after femoral bone injury partly through PAI-1 and M-CSF in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Kai Wang, Wanzhou Wang, Lei Lei, Yang Lan, Qisijing Liu, Lihua Ren, Shaowei Wu
Summary: This study conducted a systematic review and meta-analysis of existing epidemiological research to examine the associations between ambient air pollution and coagulation biomarkers. The results showed that short-term exposures to PM2.5 and O3 were associated with significant increases in coagulation biomarkers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Florence Boissiere-Michot, Caroline Mollevi, Volker Baecker, Evelyne Crapez, William Jacot
Summary: Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) have been identified as prognostic and predictive biomarkers in breast cancer, but their clinical use is limited due to the need for fresh-frozen or fresh tumor samples for quantification. This study compared the expression levels of PLAU and SERPINE1 mRNA (corresponding to uPA and PAI-1 proteins) using in situ hybridization with immunometric assay in breast tumor samples. The results showed that in situ hybridization cannot replace the immunometric assay for quantification of uPA and PAI-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Manuel Yepes, Yena Woo, Cynthia Martin-Jimenez
Summary: The neurovascular unit is a complex structure involving various cells and components that are essential for maintaining normal neuronal function. Plasminogen activators play a crucial role in regulating the function of the neurovascular unit, with dysfunction leading to neurodegenerative disorders. Research on the expression and function of tissue-type plasminogen activator and urokinase-type plasminogen activator in the neurovascular unit has provided valuable insights into neurovascular and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Bofang Wang, Baohong Gu, Tao Zhang, Xuemei Li, Na Wang, Chenhui Ma, Lin Xiang, Yunpeng Wang, Lei Gao, Yang Yu, Kewei Song, Puyi He, Yueyan Wang, Jingyu Zhu, Hao Chen
Summary: The fibrinolytic system is involved in various physiological functions and plays a significant role in the pathogenesis of many diseases. Plasminogen activator inhibitor 1 (PAI-1) is a crucial element of this system and acts as an anti-fibrinolytic agent in the normal blood clotting process. PAI-1 is involved in blood diseases, inflammation, obesity, metabolic syndrome, and tumor pathology, exhibiting a paradoxical role in different digestive system tumors.
Article
Psychology, Developmental
Minha Hong, Bomi Park, Sang Min Lee, Geon Ho Bahn, Moon Jung Kim, Sangmo Park, In-Hwan Oh, Hyesook Park
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Psychiatry
Jong Won Lee, Kyunghoon Seo, Geon Ho Bahn
PSYCHIATRY INVESTIGATION
(2020)
Correction
Psychiatry
Jong Won Lee, Kyunghoon Seo, Geon Ho Bahn
PSYCHIATRY INVESTIGATION
(2020)
Article
Psychology, Developmental
Ji Sun Hong, Young Sik Lee, Minha Hong, Bongseog Kim, Yoo Sook Joung, Hanik K. Yoo, Eui-Jung Kim, Soyoung Irene Lee, Soo Young Bhang, Seung Yup Lee, Geon Ho Bahn, Doug Hyun Han
Summary: The updated conceptualization of whole-lifespan ADHD highlights the probable persistence of impairment into adulthood. A study investigating cognition trajectories in individuals with ADHD from adolescence to mid-adulthood found deficits in complex attention, including divided attention and working memory, rather than simple attention. Patients with ADHD showed varying degrees of cognitive decline across different age intervals.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Environmental Sciences
Geon-Ho Bahn, Sang-Min Lee, Minha Hong, Seung-Yup Lee
Summary: This study aimed to examine abnormalities in iron indices and substantia nigra echogenicity in adults with ADHD using transcranial Doppler sonography (TCS). However, there were no significant differences found between patients with ADHD and controls in these aspects. Additionally, no significant changes were observed in iron indices or TCS findings after treatment with methylphenidate (MPH) medication.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Ah-Rah Lee, Geon-Ho Bahn
Summary: This study analyzed trends of first-time patients visiting the pediatric psychiatry clinic in a university hospital, finding a significant decrease in the number of male patients, higher prevalence of neurotic disorders in females, and treatment continuity affected by multiple factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Neurosciences
Geon Ho Bahn, Kyunghoon Seo
Summary: The study examined the efficiency and indications of combined medication with a stimulant and non-stimulant for ADHD in children and adults. The results suggest that combined medication can improve treatment adherence, especially for female patients. Further research in a larger sample is needed to replicate these findings and explore the indications for administering combined medication in individuals with ADHD.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Psychiatry
Duk-Soo Moon, Geon Ho Bahn
Summary: This study explores the concept of synchronized individuation between adolescents and parents through the interaction of characters in a movie and a fairy tale. The results confirm the existence of conflicts, mutual impact, ambivalent feelings for separation, selective identification, and role changes in the relationship. Sons and mothers achieve individuation through synchronization.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Duk-Soo Moon, Geon Ho Bahn
Summary: This study explored the interactions and concept of synchronized individuation during the separation-individuation process between adolescents and their parents. By learning how to navigate conflicts and ambivalent tension, adolescents and parents are able to develop new identities.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Geon Ho Bahn, Joo Seok Park
Summary: This study analyzed the case of Krystal, a fictional character in a novel, who committed suicide after facing adversity in her environment and personal life. Despite some protective factors, she was unable to cope with the loss of loved ones and ultimately took her own life, highlighting the breakdown of the social protection system for youth.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Psychiatry
Seung Yup Lee, Geon Ho Bahn
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2020)
Review
Psychiatry
Jungeun Song, Yong-Sil Kweon, Sung Hee Hong, Joonbeom Kim, Ka Hye Chun, Geon Ho Bahn, Ki-Hwan Yook, Dongwon Shin, Hyun Ju Hong
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2020)
Article
Psychiatry
Hee Jeong Yoo, Min-Hyeon Park, Jae Hyun Yoo, Minha Hong, Geon Ho Bahn
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2020)
Article
Psychiatry
Geon Ho Bahn, Young Sik Lee, Hanik K. Yoo, Eui-Jung Kim, Subin Park, Doug Hyun Han, Minha Hong, Bongseog Kim, Soyoung Irene Lee, Soo Young Bhang, Seung Yup Lee, Jin Pyo Hong, Yoo-Sook Joung
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2020)
Article
Clinical Neurology
Minha Hong, J. J. Sandra Kooij, Bongseog Kim, Yoo-Sook Joung, Hanik K. Yoo, Eui-Jung Kim, Soyoung Irene Lee, Soo-Young Bhang, Seung Yup Lee, Doug Hyun Han, Young Sik Lee, Geon Ho Bahn
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2020)