Artificial Zinc Finger DNA Binding Domains: Versatile Tools for Genome Engineering and Modulation of Gene Expression

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

(2015) M. D. Hoban et al.   BLOOD

A systematic survey of the Cys2His2 zinc finger DNA-binding landscape

(2015) Anton V. Persikov et al.   NUCLEIC ACIDS RESEARCH

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains

(2015) Thomas Gaj et al.   Jove-Journal of Visualized Experiments

Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering

(2015) Jia Liu et al.   Molecular Therapy-Nucleic Acids

Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies

(2014) Charles A. Gersbach et al.   ACCOUNTS OF CHEMICAL RESEARCH

Protein Delivery Using Cys2–His2 Zinc-Finger Domains

(2014) Thomas Gaj et al.   ACS Chemical Biology

Mechanisms of diffusional search for specific targets by DNA-dependent proteins

(2014) G. V. Mechetin et al.   BIOCHEMISTRY-MOSCOW

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

(2014) Wulan Deng et al.   CELL

Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter

(2014) P Wang et al.   GENE THERAPY

Mechanistic Heterogeneity in Site Recognition by the Structurally Homologous DNA-binding Domains of the ETS Family Transcription Factors Ets-1 and PU.1

(2014) Shuo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

(2014) Elizabeth A Heller et al.   NATURE NEUROSCIENCE

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation

(2014) Matthew R. Grimmer et al.   NUCLEIC ACIDS RESEARCH

Dissecting the function of the adult β-globin downstream promoter region using an artificial zinc finger DNA-binding domain

(2014) Joeva J. Barrow et al.   NUCLEIC ACIDS RESEARCH

An improved predictive recognition model for Cys2-His2 zinc finger proteins

(2014) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

Defining functional DNA elements in the human genome

(2014) M. Kellis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of a simple code: how transcription factors read the genome

(2014) Matthew Slattery et al.   TRENDS IN BIOCHEMICAL SCIENCES

KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions

(2013) Angelo Lupo et al.   CURRENT GENOMICS

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

(2013) J. Burdach et al.   NUCLEIC ACIDS RESEARCH

De novo prediction of DNA-binding specificities for Cys2His2 zinc finger proteins

(2013) Anton V. Persikov et al.   NUCLEIC ACIDS RESEARCH

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

(2013) Jeffry D. Sander et al.   NUCLEIC ACIDS RESEARCH

Stability of Zinc Finger Nuclease Protein Is Enhanced by the Proteasome Inhibitor MG132

(2013) Suresh Ramakrishna et al.   PLoS One

Measuring Chromatin Interaction Dynamics on the Second Time Scale at Single-Copy Genes

(2013) K. Poorey et al.   SCIENCE

Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor

(2012) Wulan Deng et al.   CELL

Epigenetic reprogramming of cancer cells via targeted DNA methylation

(2012) Ashley G. Rivenbark et al.   Epigenetics

ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions

(2012) Terrence S. Furey   NATURE REVIEWS GENETICS

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells

(2012) S. Kubicek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso

(2012) B. A. Buck-Koehntop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing the function of a  -globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain

(2012) J. J. Barrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking HIV's Attack

(2012) Carl June et al.   SCIENTIFIC AMERICAN

In the loop: long range chromatin interactions and gene regulation

(2011) A. Dean   Briefings in Functional Genomics

Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution

(2011) Ho Sung Rhee et al.   CELL

An unbiased genome-wide analysis of zinc-finger nuclease specificity

(2011) Richard Gabriel et al.   NATURE BIOTECHNOLOGY

Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays

(2011) Kathy N. Lam et al.   NUCLEIC ACIDS RESEARCH

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Origins of Specificity in Protein-DNA Recognition

(2010) Remo Rohs et al.   Annual Review of Biochemistry

Zinc finger–zinc finger interaction between the transcription factors, GATA-1 and Sp1

(2010) Miki Imanishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A zinc-finger transcriptional activator designed to interact with the  -globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

(2010) A. Wilber et al.   BLOOD

Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

(2010) Salvatore J. Orlando et al.   NUCLEIC ACIDS RESEARCH

Sequence-specific recognition of methylated DNA by human zinc-finger proteins

(2010) Nobuhiro Sasai et al.   NUCLEIC ACIDS RESEARCH

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

(2008) Morgan L. Maeder et al.   MOLECULAR CELL

Unexpected failure rates for modular assembly of engineered zinc fingers

(2008) Cherie L Ramirez et al.   NATURE METHODS