Review
Engineering, Electrical & Electronic
Seyed Ali Tabatabaei, Mohammad Zabetian Targhi, Javane Javaherchian, Marzieh Yaghoubi
Summary: Microfluidics separation has gained attention for its advantages in biological and medical studies. Spiral microchannels, as a passive separation method, show promising benefits for separating circulating tumor cells. However, a comprehensive understanding of the principles and forces in these complex channels is still necessary.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Review
Biotechnology & Applied Microbiology
Jialin Wu, Hui Fang, Jun Zhang, Sheng Yan
Summary: The advancement of microfluidics has led to significant discoveries and technologies in life sciences. However, the lack of industry standards and configurability has made the design and fabrication of microfluidic devices challenging. Modular microfluidics, which integrates standardized microfluidic modules into a complex platform, offers portability, on-site deployability, and high customization. In this review, we discuss the working mechanisms of basic microfluidic modules, their feasibility as modular components, connection approaches, advantages over integrated microfluidics, and future perspectives.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Hao Tang, Jiaqi Niu, Han Jin, Shujing Lin, Daxiang Cui
Summary: Passive and label-free microfluidic devices, with their simple design and reliance on geometric structure, have become popular in medical and bioresearch applications. This review discusses the importance of geometric design principles in passive and label-free microfluidics and summarizes the most creative innovations in microfluidic schemes such as deterministic lateral displacement, inertial microfluidics, and viscoelastic microfluidics. The aim of this review is to provide researchers with a guideline for incorporating geometric innovations into passive and label-free microfluidics.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Biochemical Research Methods
Shuntaro Mori, Takumi Ito, Hidekuni Takao, Fusao Shimokawa, Kyohei Terao
Summary: In order to accurately reproduce organs in vitro and improve drug screening efficiency and regenerative medicine research, a method to assemble cells with single-cell resolution into cell clusters has been developed. A platform using optically driven microtools in a microfluidic device was used for on-site cell assembly. The microtool, fabricated by SU-8 photolithography, captured cells through the bindings between antibodies on the microtool and surface antigens on the cell membrane. The platform has the potential to produce cell clusters resembling tissues and organs in vivo, which is important in regenerative medicine and drug screening.
IET NANOBIOTECHNOLOGY
(2023)
Review
Thermodynamics
Akash Dwivedi, Mohammad Mohsin Khan, Harveer Singh Pali
Summary: A novel framework has been employed to enhance heat transfer in heat exchangers through microchannels. The use of nanofluids as working fluids shows better thermal behavior. Flow disrupters and ceramic microchannels can also improve heat transfer performance.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Engineering, Chemical
Kaihui Cui, Kun Huang
Summary: The study reveals that the extraction and separation behaviors of target metal ions in microchannels are closely related to the changes in hydrodynamic parameters of the organic and aqueous phases, which can be controlled to achieve controllable separation of target ions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Thermodynamics
Jun Li, Pega Hrnjak
Summary: This paper presents a condenser model that incorporates a mechanistic model developed to predict the phase separation efficiency in the second header. The validation of the condenser model using R134a shows good agreement with testing results. The study reveals that downstream flow resistance also influences the separation results in the second header along with in-header fluid dynamics.
APPLIED THERMAL ENGINEERING
(2021)
Article
Mechanics
Mikhail S. Krakov
Summary: This study presents the results of a numerical simulation of two horizontal flows of miscible magnetic and non-magnetic fluids at low Reynolds numbers in a vertical uniform magnetic field. Four flow modes are found: the diffusion mixing mode with a flat diffusion front, the wave mode and two different plug flow modes.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Engineering, Chemical
Haotian Cha, Hoseyn A. Amiri, Sima Moshafi, Ali Karimi, Ali Nikkhah, Xiangxun Chen, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics is a technique that uses the finite inertia of fluid at high flow speed to manipulate and separate microparticles. Embedding periodic micro-obstacles into curvilinear channels has been found to be an effective strategy to improve inertial focusing and separation. This study systematically investigated the influence of micro-obstacles on inertial focusing and developed a high-resolution microfluidic device for particle and cell separation. The results showed that concave obstacles were more effective in tuning particle inertial focusing and separation compared to convex obstacles, and the square concave obstacle channel offered the highest separation resolution. The developed microfluidic device showed high-efficiency separation of polystyrene beads and U87MG cancer cells from blood.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Chemistry, Analytical
Xuewen Peng, Yongzhen Dong, Niu Feng, Qiaoling Wei, Peng Lu, Yiping Chen
Summary: A novel immunomagnetic separation carrier Fe3O4 @PDA-antibody was synthesized for the specific enrichment of deoxynivalenol. The Fe3O4 @PDA-antibody nano-recognizer could activate the aggregation of antigen-functionalized polystyrene beads through the antigen-antibody reaction, which was then driven into a microchannel to induce a change in current. This approach integrated extraction, immuno-reaction, and detection effectively, providing a tool for ultrasensitive detection of deoxynivalenol.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Green & Sustainable Science & Technology
Ahmed A. Ayash, Harith H. Al-Moameri, Ali Abed Salman, Arnold A. Lubguban, Roberto M. Malaluan
Summary: This study presents a novel microfluidic approach for complete separation of blood cells. The approach utilizes a polydimethylsiloxane serpentine microchannel with a series of electrodes, providing two separation zones. The design exploits the unique channel configuration and the inherent differences in dielectric properties of the three blood cell types to achieve size-based sorting. Platelets are separated in the first zone due to their larger dielectrophoretic force compared to red and white blood cells. The model developed in this work demonstrates the feasibility of the proposed approach, showing complete separation of blood content across different flow rates and AC frequencies.
Article
Mathematics
Cesar A. Valencia, David A. Torres, Clara G. Hernandez, Juan P. Escandon, Juan R. Gomez, Rene O. Vargas
Summary: This study analyzes the transient multilayer electro-osmotic flow through an annular microchannel with hydrophobic walls. Different interfacial phenomena and influencing factors are studied. The electric potential distribution and flow field are determined using linearized Poisson-Boltzmann and Cauchy momentum equations. The results show that the flow behavior exhibits oscillation, which is strongly influenced by the dimensionless relaxation time. The hydrodynamic slip on the channel walls contributes to the release of energy stored in the fluids at the start-up of the flow. This research aims to predict the parallel flow behavior in microfluidic devices under electro-osmotic effects.
Article
Mechanics
M. Majhi, A. K. Nayak, Subhajyoti Sahoo
Summary: This study investigates the mixing efficiency and the enhancement of electro-osmotic flow over a hydrophobic structured microchannel with a nozzle-diffuser under an external electric field. By varying the interfacial surface zeta potential, a strong convection effect is induced between two injecting fluids for different Reynolds numbers. The numerical simulation incorporates the Poisson-Nernst-Plank model to handle the thick and thin diffuse layers formed by a non-Newtonian electrolyte solution. The results showed that hydrodynamic slip increased flow velocity, while heterogeneous zeta potential generated a backflow that improved mixing efficiency. Moreover, the study discussed the mixing performance of different types of fluids and explored the effect of various physio-chemical parameters on mixing efficiency.
Article
Materials Science, Multidisciplinary
Daniel Widerker, Federico Paratore, Moran Bercovici, Govind Kaigala
Summary: This paper introduces a device and method for rapid prototyping of biochips using a fluidic biomill for mechanical structuring and biofunctionalization of microfluidic channels. The study demonstrates that this method can fabricate fully functional biochips in a short period of time.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Biochemical Research Methods
Andrew S. Clark, Adriana San-Miguel
Summary: We have developed two microfluidic lobe filters inspired by the filtration mechanism of manta rays to address clogging issues. These filters can efficiently filtrate particles around 10-30 μm with high throughput and precise control, showing increased filtration efficiency with fluid flow rate.
Article
Chemistry, Multidisciplinary
Wujun Zhao, Taotao Zhu, Rui Cheng, Yufei Liu, Jian He, Hong Qiu, Lianchun Wang, Tamas Nagy, Troy D. Querec, Elizabeth R. Unger, Leidong Mao
ADVANCED FUNCTIONAL MATERIALS
(2016)
Article
Biochemical Research Methods
Yilong Zhou, Dhileep Thanjavur Kumar, Xinyu Lu, Akshay Kale, John DuBose, Yongxin Song, Junsheng Wang, Dongqing Li, Xiangchun Xuan
Article
Chemistry, Multidisciplinary
Taotao Zhu, Rui Cheng, Gareth R. Sheppard, Jason Locklin, Leidong Mao
Article
Nanoscience & Nanotechnology
Dhileep Thanjavur Kumar, Yilong Zhou, Vincent Brown, Xinyu Lu, Akshay Kale, Liandong Yu, Xiangchun Xuan
MICROFLUIDICS AND NANOFLUIDICS
(2015)
Article
Nanoscience & Nanotechnology
Hyomin Lee, Chang-Hyung Choi, Alireza Abbaspourrad, Chris Wesner, Marco Caggioni, Taotao Zhu, David A. Weitz
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Chemistry, Multidisciplinary
Hyomin Lee, Chang-Hyung Choi, Alireza Abbaspourrad, Chris Wesner, Marco Caggioni, Taotao Zhu, Saraf Nawar, David A. Weitz
ADVANCED MATERIALS
(2016)
Article
Chemistry, Multidisciplinary
Chang-Hyung Choi, Hyomin Lee, Alireza Abbaspourrad, June Hwan Kim, Jing Fan, Marco Caggioni, Chris Wesner, Taotao Zhu, David A. Weitz
ADVANCED MATERIALS
(2016)
Article
Physics, Applied
Yilong Zhou, Xiangchun Xuan
APPLIED PHYSICS LETTERS
(2016)
Article
Materials Science, Multidisciplinary
Yilong Zhou, Le Song, Liandong Yu, Xiangchun Xuan
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2016)
Article
Nanoscience & Nanotechnology
Yilong Zhou, Le Song, Liandong Yu, Xiangchun Xuan
MICROFLUIDICS AND NANOFLUIDICS
(2017)
Article
Physics, Applied
James J. Wilbanks, Garrett Kiessling, Jian Zeng, Cheng Zhang, Tzuen-Rong Tzeng, Xiangchun Xuan
JOURNAL OF APPLIED PHYSICS
(2014)
Article
Engineering, Electrical & Electronic
John DuBose, Junjie Zhu, Saurin Patel, Xinyu Lu, Nathaniel Tupper, John M. Stonaker, Xiangchun Xuan
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2014)
Article
Nanoscience & Nanotechnology
Rui Cheng, Taotao Zhu, Leidong Mao
MICROFLUIDICS AND NANOFLUIDICS
(2014)
Article
Multidisciplinary Sciences
Zhaojie Deng, Sam Arsenault, Cristian Caranica, James Griffith, Taotao Zhu, Ahmad Al-Omari, Heinz-Bernd Schuettler, Jonathan Arnold, Leidong Mao
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Analytical
Qi Chen, Di Li, Jianhan Lin, Maohua Wang, Xiangchun Xuan
ANALYTICAL CHEMISTRY
(2017)
