Review
Biochemistry & Molecular Biology
Aakash Basu, Dmitriy G. Bobrovnikov, Taekjip Ha
Summary: The mechanical deformations of DNA are involved in nucleoprotein interactions and DNA manipulation events. Progresses in single-molecule, structural, and computational methods have characterized the mechanical properties of DNA, and sequencing technology has allowed measuring how these properties vary with sequence and epigenetic modifications. These technological advancements have contributed to the emerging idea that variations in the mechanical properties of DNA play a fundamental role in regulating diverse processes involved in chromatin organization at a genome-wide level.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Physics, Multidisciplinary
Thomas Andrew Waigh, Nickolay Korabel
Summary: A wide variety of phenomena in cellular and molecular biology involve anomalous transport, which is often heterogeneous in time and space. Single anomalous exponents and generalized diffusion coefficients fail to adequately describe these phenomena, requiring different experimental techniques and theoretical tools for analysis. High throughput analysis techniques and machine learning play important roles in the study of anomalous transport.
REPORTS ON PROGRESS IN PHYSICS
(2023)
Review
Chemistry, Multidisciplinary
Shuyan Wang, Dan Wang, Yaou Duan, Zhidong Zhou, Weiwei Gao, Liangfang Zhang
Summary: Cellular nanosponges, as host decoys, have shown great potential for biological neutralization applications. By mimicking susceptible host cells, they can create function-driven and broad-spectrum neutralization solutions against various pathological agents.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Francisco Ramos-Martin, Nicola D'Amelio
Summary: Biomembranes serve as the first line of defense for cells, and phospholipids play a crucial role in regulating their functions. The assembly of different phospholipids determines the physical-chemical properties of the membrane and affects the recognition of cell types by membrane-targeting molecules.
Article
Chemistry, Multidisciplinary
Sungmin Nam, Yung-Hao Lin, Taeyoon Kim, Ovijit Chaudhuri
Summary: In dense collagen gels, single cancer cells generate substantial pushing forces to facilitate cell division without the need for cell spreading or matrix degradation. These forces arise from a combination of interpolar spindle elongation and cytokinetic ring contraction.
Review
Nanoscience & Nanotechnology
Haixiao Wan, Duo Xu, Lijuan Gao, Li-Tang Yan
Summary: This article provides a comprehensive review on the major types of entropy in biological systems and their underlying physical principles. It focuses on the physical mechanisms arising from entropy in the cellular uptake process and discusses the remaining challenges and future directions for manipulating entropy-mediated nanoparticle cellular uptake.
Article
Chemistry, Multidisciplinary
Yi-Feng Wang, Qingrong Zhang, Falin Tian, Hongda Wang, Yufei Wang, Xiaowei Ma, Qianqian Huang, Mingjun Cai, Yinglu Ji, Xiaochun Wu, Yaling Gan, Yan Yan, Kenneth A. Dawson, Shutao Guo, Jinchao Zhang, Xinghua Shi, Yuping Shan, Xing-Jie Liang
Summary: This study investigated the internalization behaviors of rod-shaped nanostructures with different aspect ratios using atomic force microscopy, transmission electron microscopy, and molecular dynamic simulation. It revealed that gold nanorods are endocytosed in an intermittent rotation manner and the internalization force and time are positively correlated with the aspect ratios. The study also found that internalization speed is negatively correlated with internalization time.
Editorial Material
Multidisciplinary Sciences
J. Pedro de Souza, Howard A. Stone
Summary: Protein condensation can not only form membraneless organelles, but also regulate the availability of water.
Editorial Material
Multidisciplinary Sciences
Chase P. Broedersz, Pierre Ronceray
Summary: This paper discusses how the Jarzynski equality updates the second law of thermodynamics by extending the physics of transformations from steam engines to molecular motors.
Article
Biochemistry & Molecular Biology
Meewhi Kim, Ilya Bezprozvanny
Summary: The sigma 1 receptor (S1R) is an important therapeutic target for neurological disorders. Through structural modeling and bioinformatics analysis, a model was proposed suggesting that S1R may exist in two distinct conformations. The equilibrium between these conformations plays a crucial role in the biological function of S1R in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemical Research Methods
Hailekiros Gebretsadik, Getu Kahsay, Erwin Adams, Ann Van Schepdael
Summary: This review provides a comprehensive overview of different capillary electrophoresis-based techniques used for the analysis of erythropoietin isoforms. The importance of erythropoietin in clinical practice and the necessity for accurate analysis of its isoforms are discussed. Various techniques that have been used for erythropoietin isoform analysis are described, with a focus on capillary zone electrophoresis and capillary isoelectric focusing. The advantages, drawbacks, and potential future directions of these techniques are also discussed.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Review
Cell Biology
Dingxi Zhou, Mariana Borsa, Anna Katharina Simon
Summary: The ageing population poses challenges to health and social care, with deteriorating immune systems contributing to chronic age-related diseases. More knowledge is needed on the aged immune system for developing COVID-19 treatments, with cellular senescence playing a key role in immune ageing. Deepening the understanding of immune cell senescence may lead to potential druggable pathways for reversing immune ageing.
Review
Physiology
Richa Aishwarya, Chowdhury S. Abdullah, Mahboob Morshed, Naznin Sultana Remex, Md Shenuarin Bhuiyan
Summary: The Sigma 1 receptor is a multifunctional inter-organelle signaling protein with a diverse role in cellular survival, and mutations in Sigmar1 have been linked to various diseases. Changes in Sigmar1's subcellular localization, expression, and signaling are associated with the progression of diseases such as neurodegenerative diseases and cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Rivkah Rogawski, Michal Sharon
Summary: Biological mass spectrometry (MS) is a powerful method for the structural analysis of endogenous protein complexes. It provides valuable information about complex stoichiometry, topology, stability, and activity. This review discusses methods for isolating endogenous complexes, various MS approaches, and future directions for these methods.
Review
Chemistry, Analytical
Boguslaw Buszewski, Dominika Blonska, Ewa Klodzinska, Marek Konop, Anna Kubesova, Jiri Salplachta
Summary: In modern medical diagnostics, fast and accurate identification of pathogens is crucial for public health due to factors such as population growth and bacterial resistance to antibiotics. However, most current methods for identifying pathogens by their genetic code are expensive and slow. This review paper emphasizes the problems associated with pathogen analysis and identification and highlights the potential of electromigration techniques and spectrometric methods for effective detection and identification.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)