Journal
BIOMICROFLUIDICS
Volume 4, Issue 1, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3310930
Keywords
acoustic streaming; bioMEMS; biosensors; chemical sensors; drops; finite element analysis; flow visualisation; microfluidics; microsensors; surface acoustic wave sensors; surface acoustic wave transducers
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A droplet-based micro-total-analysis system involving biosensor performance enhancement by integrated surface-acoustic-wave (SAW) microstreaming is shown. The bioreactor consists of an encapsulated droplet with a biosensor on its periphery, with in situ streaming induced by SAW. This paper highlights the characterization by particle image tracking of the speed distribution inside the droplet. The analyte-biosensor interaction is then evaluated by finite element simulation with different streaming conditions. Calculation of the biosensing enhancement shows an optimum in the biosensor response. These results confirm that the evaluation of the Damkoumlhler and Peclet numbers is of primary importance when designing biosensors enhanced by streaming.
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