Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Article
Chemistry, Analytical
Shahrzad Talebian, Mehdi Javanmard
Summary: The majority of existing automated cell counter instruments are complex, expensive, and bulky, limiting their use to laboratories. Researchers have developed a portable smartphone-based particle counting platform to address the lack of accessible cell counting technology in rural and developing areas. This technology utilizes a smartphone camera and custom-developed algorithm to detect and count particles in sample solutions with high accuracy and wide applicability.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Chemistry, Analytical
Zenglin Dang, Yuning Jiang, Xin Su, Zhihao Wang, Yucheng Wang, Zhe Sun, Zheng Zhao, Chi Zhang, Yuming Hong, Zhijian Liu
Summary: This paper provides a taxonomical elucidation of microfluidic chip-based particle counters, classifying them into optical-based counters, electrical-based particle counters, and other counters. It describes the working principles of each type and methods to enhance sensitivity and throughput, and also analyzes future trends related to each type of counter.
Article
Chemistry, Analytical
Ruben R. Lopez, Luz-Maria Sanchez, Anas Alazzam, Julia V. Burnier, Ion Stiharu, Vahe Nerguizian
Summary: The shape and dimensions of a micromixer are crucial for the mixing efficiency, which can be quantified accurately using numerical and experimental models. The results from the two methods showed high similarity, demonstrating their reliability and effectiveness in evaluating micromixer performance.
Article
Materials Science, Biomaterials
Marco E. Miali, Wei Chien, Thomas Lee Moore, Alessia Felici, Anna Lisa Palange, Michele Oneto, Dmitry Fedosov, Paolo Decuzzi
Summary: A microfluidic chip is designed and validated as a platform to assess the mechanical behavior of fluid-borne particles. The behavior of particles with different geometries and mechanical attributes under flow conditions is investigated through experimental and computational methods.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemical Research Methods
Federica Torrisi, Giovanna Stella, Francesca M. Guarino, Maide Bucolo
Summary: This paper presents a combination of a cell counting algorithm and a velocity algorithm based on a Digital Particle Image Velocimetry (DPIV) method to study the collective behavior of micro-particles in response to hydrodynamic stimuli. A wide experimental campaign was conducted using micro-particles of different natures and diameters, such as living cells and silica beads. The proposed data analysis procedure based on the DPIV-based algorithm and a custom counting algorithm allows for the extrapolation of micro-particles velocities and the obtainment of the instantaneous micro-particles number.
Article
Chemistry, Analytical
Xiao Zhou, Yuanhang Mao, Miao Gu, Zhen Cheng
Summary: Researchers developed a microfluidic system embedded with a weakly supervised cell counting network (WSCNet) to generate microfluidic droplets, evaluate their quality, and accurately recognize the locations of encapsulated cells.
Article
Computer Science, Interdisciplinary Applications
Chiara Santarelli, Monica Carfagni, Luciano Alparone, Alberto Arienzo, Fabrizio Argenti
Summary: In this paper, a multimodal medical image fusion method based on multiresolution analysis (MRA) is proposed to combine the geometric content of magnetic resonance imaging (MRI) and the elasticity information of magnetic resonance elastography (MRE). The proposed method is evaluated quantitatively and qualitatively, and the results show that it enables an effective evaluation of the elasticity information and geometric details of the examined organs.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Acoustics
Lizhu Liu, Jian Zhou, Kaitao Tan, Hui Zhang, Xin Yang, Huigao Duan, YongQing Fu
Summary: This study develops a simplified but effective 3D SSAW microfluidic model to investigate the separation and manipulation of particles. The model considers propagation attenuation of surface waves to increase modeling accuracy and simplifies the modeling of piezoelectric substrates and microchannel walls to reduce computational complexity. Simulation results are compared with experimental data, demonstrating the reliability of the model.
Review
Engineering, Chemical
Ioannis H. Karampelas, Jenifer Gomez-Pastora
Summary: The demand for precise separation of particles, cells, and other biological matter has increased in recent years, leading to increased scientific interest in the topic. This article establishes the theoretical basis for fluid flow and particle separation and summarizes computational work done in the field of particle and cell separation, with a focus on magnetic, dielectric, and acoustic methods.
Review
Computer Science, Artificial Intelligence
Lijia Deng, Qinghua Zhou, Shuihua Wang, Juan Manuel Gorriz, Yudong Zhang
Summary: This study proposed a three-tier standardised dataset taxonomy that helps researchers optimize dataset usage and improve AI algorithm performance in specific fields. It also introduced a new evaluation index for dataset clarity and discussed and evaluated existing datasets. The research found that progress in small-scale dataset research has slowed down, while large and hyper-scale datasets are reaching saturation. Therefore, researchers are exploring the combination of multiple approaches and the need for targeted datasets to further advance crowd counting research.
CAAI TRANSACTIONS ON INTELLIGENCE TECHNOLOGY
(2023)
Article
Oncology
Laura Furia, Simone Pelicci, Federica Perillo, Maddalena M. Bolognesi, Pier Giuseppe Pelicci, Federica Facciotti, Giorgio Cattoretti, Mario Faretta
Summary: In situ multiplexing analysis and in situ transcriptomics are revolutionary tools for understanding the molecular basis of cancer and advancing personalized medicine. To achieve the best resolution and sensitivity, continuous interplay between different technologies is required. We propose a new experimental pipeline that alternates between automated and manual procedures to optimize the cost-to-benefit ratio in multiplexing experiments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Narciso, Jorge Otero, Daniel Navajas, Ramon Farre, Isaac Almendros, Nuria Gavara
Summary: A new image processing algorithm has been developed for quantitative analysis of DNA content in (de)cellularized tissues, offering a faster, simpler, and more comprehensive alternative to traditional methods. This method can be applied to both native and decellularized tissues, providing a means to quantify DNA content and assess decellularization procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mechanics
Benjamin Owen, Timm Kruger
Summary: We investigate the formation and stability of identical soft capsules in channel flow under mild inertia. By using a combination of numerical methods, we simulate the elastic particles in flow and find new trajectory types that have not been observed for pairs of rigid particles. Our results show that stabilisation of the axial distance occurs after lateral migration of the particles, and during the later phase of pair formation, particles undergo damped oscillations that are independent of initial conditions.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Biochemical Research Methods
Wei-Feng Fang, Miao-Hsing Hsu, Yu-Tzu Chen, Jing-Tang Yang
Article
Biophysics
Yu-Tzu Chen, Yen-Cheng Liu, Wei-Feng Fang, Chao-Jyun Huang, Shih-Kang Fan, Wen-Jone Chen, Wei-Tien Chang, Chien-Hua Huang, Jing-Tang Yang
BIOSENSORS & BIOELECTRONICS
(2013)
Article
Engineering, Environmental
Yu-Tzu Chen, Kuan-Hong Chen, Wei-Feng Fang, Sheng-Hung Tsai, Jim-Min Fang, Jing-Tang Yang
CHEMICAL ENGINEERING JOURNAL
(2011)
Article
Engineering, Environmental
Kuan-Hung Chen, Wei-Feng Fang, Yu-Tzu Chen, Jim-Min Fang, Jing-Tang Yang
CHEMICAL ENGINEERING JOURNAL
(2012)
Article
Engineering, Chemical
Jing-Tang Yang, Wei-Feng Fang, Kai-Yang Tung
CHEMICAL ENGINEERING SCIENCE
(2008)
Article
Biochemical Research Methods
Miao-Hsing Hsu, Wei-Feng Fang, Yu-Hsuan Lai, Jing-Tang Yang, Tsung-Lin Tsai, Dar-Bin Shieh
Article
Biochemical Research Methods
Wei-Feng Fang, Shang-Chieh Ting, Ching-Wen Hsu, Yu-Tzu Chen, Jing-Tang Yang
Article
Biochemical Research Methods
Shih-Kang Fan, Cheng-Pu Chiu, Ching-Hsiang Hsu, Shih-Chiang Chen, Li-Lin Huang, Yen-Hao Lin, Wei-Feng Fang, Jem-Kun Chen, Jing-Tang Yang
Article
Nanoscience & Nanotechnology
Yu-Tzu Chen, Wei-Feng Fang, Yen-Cheng Liu, Jing-Tang Yang
MICROFLUIDICS AND NANOFLUIDICS
(2011)
Article
Nanoscience & Nanotechnology
Yu-Tzu Chen, Wei-Chun Chang, Wei-Feng Fang, Shang-Chieh Ting, Da-Jeng Yao, Jing-Tang Yang
MICROFLUIDICS AND NANOFLUIDICS
(2012)
Article
Nanoscience & Nanotechnology
Szu-I Yeh, Wei-Feng Fang, Horn-Jiunn Sheen, Jing-Tang Yang
MICROFLUIDICS AND NANOFLUIDICS
(2013)
Article
Chemistry, Analytical
Wei-Feng Fang, Jing-Tang Yang
SENSORS AND ACTUATORS B-CHEMICAL
(2009)
Article
Chemistry, Analytical
Wei-Feng Fang, Wen-Jone Chen, Jing-Tang Yang
SENSORS AND ACTUATORS B-CHEMICAL
(2014)