Journal
BIOMETRICS
Volume 65, Issue 2, Pages 599-608Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1541-0420.2008.01096.x
Keywords
Case-control studies; Conditional likelihood; Counter-matching; Counting processes; Measurement error; Multivariate survival data; Partial likelihood; Radiation epidemiology
Funding
- NCI [CA97397, CA42949]
- NIEHS [5P30 ES07048]
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Methods for the analysis of individually matched case-control studies with location-specific radiation dose and tumor location information are described. These include likelihood methods for analyses that just use cases with precise location of tumor information and methods that also include cases with imprecise tumor location information. The theory establishes that each of these likelihood based methods estimates the same radiation rate ratio parameters, within the context of the appropriate model for location and subject level covariate effects. The underlying assumptions are characterized and the potential strengths and limitations of each method are described. The methods are illustrated and compared using the WECARE study of radiation and asynchronous contralateral breast cancer.
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