Article
Biochemistry & Molecular Biology
Samantha D. Francis Stuart, Alice R. Villalobos
Summary: This study demonstrates that the choroid plexus adapts to cadmium-induced cellular stress by up-regulating glutathione (GSH) synthesis, while zinc may provide cellular protection independently of GSH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Z. Pardo, I Seiquer
Summary: Zinc supplementation was found to reduce cell membrane damage, alleviate oxidative stress, promote antioxidant enzyme activity, and protect intestinal barrier function under heat stress conditions, which may be a beneficial nutritional strategy against intestinal damage caused by high temperatures.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agronomy
Roger H. Tang, Peter D. Erskine, Philip Nti Nkrumah, Guillaume Echevarria, Antony van der Ent
Summary: Metallophytes are plants that can tolerate extreme metal concentrations in soil. A study on the Dugald River gossan in Australia found that there was no direct relationship between the occurrence of metallophytes and prevailing soil metal concentrations. Crotalaria novae-hollandiae was identified as a strong polymetallic indicator-type metallophyte that can accumulate high concentrations of metals in its leaves.
Article
Agronomy
Roger H. Tang, Philip N. Nkrumah, Peter D. Erskine, Antony van der Ent
Summary: The study aimed to investigate zinc-cadmium tolerance in C. novae-hollandiae and compare it with C. cunninghamii. The results showed that C. novae-hollandiae accumulated high levels of zinc and cadmium in its shoots, with an increase in biomass. However, its tolerance for cadmium was limited. This study also suggested that C. novae-hollandiae may have different mechanisms for element uptake and tolerance compared to other well-studied zinc-cadmium hyperaccumulators.
Article
Multidisciplinary Sciences
Gausiya Bashri, Shikha Singh, Sheo Mohan Prasad, Mohammad Javed Ansari, Salma Usmani, Saleh Alfarraj, Sulaiman Ali Alharbi, Marian Brestic
Summary: The study found that cytokinins can mitigate the damaging effects of cadmium stress on plant growth by regulating the activity of antioxidant enzymes, reducing H2O2 accumulation, and improving the growth and photosynthetic activity of trigonella seedlings.
Article
Pharmacology & Pharmacy
Changwei Zou, Ying Chen, Hongyu Li, Wenyu Li, Jin Wei, Ziyan Li, Xinliang Wang, Tingtao Chen, Hong Huang
Summary: Cadmium exposure is a global problem with limited treatment options. A genetically modified strain of Escherichia coli that expresses metallothionein was found to effectively bind cadmium and reduce cadmium levels in the liver. The strain also improved liver function and restored the disrupted microbial ecology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junhui Zhan, Wenli Zou, Shuangyuyan Li, Jichun Tang, Xiang Lu, Lijun Meng, Guoyou Ye
Summary: In rice, OsNAC15, a NAM/CUC2-like transcription factor, plays a significant role in zinc deficiency tolerance and cadmium stress tolerance by regulating the transcription of ZIP family genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Anna Mittag, Christian Hoera, Alexander Kaempfe, Martin Westermann, Jochen Kuckelkorn, Thomas Schneider, Michael Glei
Summary: The study found that zinc oxide nanoparticles of different sizes have cellular uptake and toxic effects on human intestinal cells, especially showing cytotoxicity at high concentrations, which can accelerate cell apoptosis and death.
Article
Environmental Sciences
Samrah Afzal Awan, Imran Khan, Muhammad Rizwan, Muhammad Atif Irshad, Wang Xiaosan, Xinquan Zhang, Linkai Huang
Summary: Cadmium (Cd) is a toxic pollutant that harms animals and plants. The natural antioxidant melatonin can improve Cd-stress tolerance, but its potential role in reducing Cd stress and resilience mechanisms in pearl millet is unclear. This study found that exogenous melatonin mitigated Cd toxicity and enhanced growth and antioxidant defense system in pearl millet.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Anna Mittag, Patricia Owesny, Christian Hoera, Alexander Kaempfe, Michael Glei
Summary: The study found that ZnO NP treatment did not have a significant impact on the permeability and cell damage of the intestinal barrier model, but it did decrease cellular zinc uptake.
Article
Biochemistry & Molecular Biology
Thaise Boeing, Silvia Speca, Priscila de Souza, Anthony Martin Mena, Benjamin Bertin, Pierre Desreumax, Luisa Mota da Silva, Sergio Faloni de Andrade, Laurent Dubuqoy
Summary: Luteolin can reduce inflammation and oxidative stress induced by irinotecan in Caco-2 cells by upregulating the expression of PPAR gamma, HO-1, and SOD genes, and decreasing the expression of IL-1 beta and iNOS. However, when PPAR gamma expression is downregulated, luteolin loses this effect.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Mireille Koudoufio, Francis Feldman, Lena Ahmarani, Edgard Delvin, Schohraya Spahis, Yves Desjardins, Emile Levy
Summary: The study found that proanthocyanidins (PACs) can reduce lipid peroxidation, decrease inflammation, improve lipid and glucose homeostasis, and enhance insulin sensitivity. This may be achieved through increasing antioxidants and regulating key metabolic pathways.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Lina Chouchene, Kaouthar Kessabi, Marie-Madeleine Gueguen, Olivier Kah, Farzad Pakdel, Imed Messaoudi
Summary: This study provides new insights into the mechanisms of cadmium-induced toxicity in zebrafish larvae and the potential role of zinc in reversing these harmful effects. The results suggest that cadmium interferes with zinc metabolism, leading to its depletion and oxidative stress. However, supplementation of zinc can partially reverse the toxic effects of cadmium, possibly through its interaction with the toxic metal and improvement of oxidative status.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Antonio Speciale, Claudia Muscara, Maria Sofia Molonia, Giovanni Toscano, Francesco Cimino, Antonella Saija
Summary: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gut, and new plant-derived therapies may offer alternative treatments. Cynara cardunculus leaves, a source of bioactive polyphenols, have positive effects on the digestive tract, potentially useful for preventing and treating inflammatory intestinal diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Hanuma Naik Ramavath, Venu Konda, Raghu Pullakhandam
Summary: Previous studies have shown that quercetin inhibits iron transport by down-regulating the expression of ferroportin (FPN1), an iron export protein. We investigated the effect of quercetin on iron uptake, transport, and expression of iron transporters in intestinal cells. The results suggest that quercetin inhibits basolateral iron transport by down-regulating the expression of CDX2-dependent hephaestin (HEPH) via inhibition of the PI3K pathway.