Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 108, Issue -, Pages 558-564Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.09.045
Keywords
Trichophyton rubrum; Dermatophytosis; Dipyrithione; Guinea pigs; Antifugal activity
Funding
- Hong Kong Baptist University (HKBU) Interdisciplinary Research Matching Scheme [RC-IRMS/15-16/02]
- Faculty Research Grants, Hong Kong Baptist University [FRG2/17-18/103]
- Natural Science Foundation of Shenzhen [JCYJ20150324141711557, JCYJ20150525092941057]
- Shenzhen Science and Technology Innovation Committee of China [CXZZ20150601110000604, ZDSYS201506031617582]
- National Natural Science Foundation of China [31670360, 21402166, 81503215, 31500285]
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The treatment of dermatophytosis has improved considerably over the past several decades following the introduction of the oral antifungals such as azoles and amphotericin B. However, these drugs have had limited success because the treated fungi often develop drug resistance, resulting in recurrence when applied in various topical formulations. Thus, there are constant needs for new topical agents that are effective against dermatophytosis. Dipyrithione is an attractive candidate to become an antifungal agent due to its broad spectrum of antimicrobial activities. In this study, we determined that dipyrithione could potently inhibit the growth of Trichophyton rubrum, which is the most common cause of dermatophytosis. The MIC50 value of dipyrithione against T. rubrum was measured as 6.03 mu M, as compared with miconazole (MIC50: 1.38 mu M). Additionally, the compound caused morphological changes in the fungi, which was examined using the morphological interference assay. The in vivo experiment further revealed that dipyrithione had a healing effect on the skin of guinea pigs infected with T. rubrum. Our studies have demonstrated that dipyrithione had a potent antifungal activity in vitro and in vivo, suggesting that it could be formulated as a potential antifungal lead compound in search for novel therapeutic agents against dermatophytosis.
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