Article
Pharmacology & Pharmacy
Zhaojuan Guo, Pin Li, Chunguo Wang, Qianjun Kang, Can Tu, Bingqian Jiang, Jingxuan Zhang, Weiling Wang, Ting Wang
Summary: This study found that the ethanol extraction process aggravated the hepatotoxicity of Psoraleae Fructus, with bavachin, psoralidin, bavachinin, neobavaisoflavone, and bakuchiol identified as the main toxic ingredients. These constituents induced cell apoptosis, increased lipid accumulation and reactive oxygen species levels, while decreasing mitochondrial membrane potential. The mechanism may be associated with oxidative stress and mitochondrial damage-mediated apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Xifeng Shan, Ling Liu, Gang Li, Kexin Xu, Bingyan Liu, Wei Jiang
Summary: In this study, the cytotoxic effects of PM2.5, BC, and Kaolin were investigated using human bronchial epithelial cells. BC and Kaolin mainly induced cell necrosis, while PM2.5 caused both apoptosis and necrosis. Excess ROS production was involved in organelle damage and cell death, with ROS playing a more significant role in BC-induced cytotoxicity compared to Kaolin. Removal of ROS partially mitigated PM2.5-induced apoptosis and necrosis, suggesting the existence of ROS-dependent and ROS-independent mechanisms in PM2.5 toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Qian Gao, Zhong-Yuan Zhou, Ya-Ning He, Ming-Hui Dong, Zhao-Ning Wang, Hong-Mei Chen
Summary: This study evaluated the toxicity of BDE-47 towards RAW264.7 mouse macrophage cells and found that it caused a decrease in cell viability, an increase in apoptosis, and inhibition of phagocytosis. The mechanisms involved mitochondrial pathway-induced cell apoptosis and oxidative damage. Treatment with an antioxidant reversed the effects, while treatment with a ROS-inducer exacerbated them. These findings highlight the critical role of oxidative damage in BDE-47-induced suppression of immune function.
Article
Pharmacology & Pharmacy
Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Meng
Summary: In this study, five cardiac glycosides were extracted from natural plants, and Lan C was identified as the most potent anti-cholangiocarcinoma compound. Lan C inhibited the growth and induced apoptosis of cholangiocarcinoma cells, without toxic effects on normal cells. Mechanistically, Lan C downregulated the expression of STAT3, leading to apoptosis. Therefore, Lan C may serve as a promising candidate for the treatment of cholangiocarcinoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Anberitha T. Matthews, Hitesh Soni, Katherine E. Robinson-Freeman, Theresa A. John, Randal K. Buddington, Adebowale Adebiyi
Summary: Doxorubicin (DOX), a chemotherapeutic agent, can induce fetal nephrotoxicity by inhibiting proliferation and inducing death of fetal pig glomerular mesangial cells (GMCs). DOX treatment reduces TRPC6 protein expression, leading to mitochondrial ROS generation and cell death in GMCs. The DOX-induced fetal pig GMC apoptosis is independent of TRPC6 upregulation but requires mtROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jianrong Zheng, Liao Zeng, Mingqing Tang, Hongjun Lin, Chao Pi, Ruian Xu, Xiuling Cui
Summary: Compound 1 exhibited potent anti-HCC activity by inducing cell cycle arrest and apoptosis through mitochondrial pathway, suggesting it as a promising candidate for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Engineering, Environmental
Guoliang Chen, Mingxing Wang, Panpan Zhu, Guixue Wang, Tingzhang Hu
Summary: Pyraoxystrobin (SYP-3343), a newly-invented strobilurin fungicide, exhibits high toxicity to aquatic organisms, particularly in zebrafish embryos, through affecting cell cycle, mitochondrial membrane potential, and reactive oxygen species generation. This toxicity is dose- and time-dependent, inducing apoptosis in zebrafish embryos.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hulya Gizem Ozkan, Vanrajsinh Thakor, Hong-Gui Xu, Galyna Bila, Rostyslav Bilyy, Daria Bida, Martin Boettcher, Dimitrios Mougiakakos, Rainer Tietze, Andriy Mokhir
Summary: Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are weak points of cancer cells. Designing highly potent anticancer drugs that target both ROS and mitochondria is a valid therapeutic strategy. However, limiting the drug effects to cancer cells without affecting normal ones remains a challenge. In this study, we developed novel aminoferrocene derivatives that are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells but not normal cells, and exhibit anticancer effects in vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Sonia Poirault-Chassac, Valerie Nivet-Antoine, Amandine Houvert, Alexandre Kauskot, Evelyne Lauret, Rene Lai-Kuen, Isabelle Dusanter-Fourt, Dominique Baruch
Summary: This study demonstrates the functional coupling between ROS and mitochondrial fission in megakaryocytes, which is crucial for the initiation of thrombopoiesis. The findings provide new molecular cues that control the initiation of platelet biogenesis and may help elucidate some unexplained thrombocytopenia.
Article
Engineering, Environmental
Yinkun Sun, Dongwei Lu, Hui Zhang, Guanjin Liu, Yichao Hu, Haijiao Xie, Jun Ma
Summary: Oxygen vacancies in metal oxide electrocatalytic membranes have a dual role in generating and transforming ROS, acting as promoters at low concentrations but as inhibitors at high concentrations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fernando Joel Scariot, Ana Paula Longaray Delamare, Sergio Echeverrigaray
Summary: This study investigated the effects of chlorothalonil on Saccharomyces cerevisiae during alcoholic fermentation using flow cytometry. The results showed that chlorothalonil bound to yeast cell and mitochondrial membranes, resulting in necrotic cell death and reduced metabolic activity. There was also an increase in reactive oxygen species and apoptotic cell death. However, surviving cells were able to adapt and continue growing and fermenting. Interestingly, sub-doses of chlorothalonil protected yeast cell membrane integrity during alcoholic fermentation.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
